C7736
Anti-Centrin antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CEN1, Anti-CETN
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
microarray
western blot
western blot
Species reactivity:
human
Citations:
15
Technique(s):
microarray: suitable
western blot: 1:2,000 using 293-T exp.Hu.Centrin-1LY117608 or 293-T exp.Hu.Centrin1-FLAG LY401316
western blot: 1:2,000 using 293-T exp.Hu.Centrin-1LY117608 or 293-T exp.Hu.Centrin1-FLAG LY401316
Uniprot accession no.:
Product Name
Anti-Centrin antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 21 kDa
species reactivity
human
technique(s)
microarray: suitable
western blot: 1:2,000 using 293-T exp.Hu.Centrin-1LY117608 or 293-T exp.Hu.Centrin1-FLAG LY401316
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CETN1(1068)
Application
Anti-Centrin antibody produced in rabbit has been used in:
- immunofluorescence
- immunoblotting
- immunofluorescence microscopy
Biochem/physiol Actions
Centrin has a fundamental role in the microtubule-organizing center (MTOC) structure and function. These proteins has imperative roles in centrosome positioning and segregation. Centrin also participates in cytokinesis and cell cycle progression.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Centrins are acidic proteins, that are usually found in all eukaryotes. Centrin 1 (CETN1), an intron-less gene is mapped on human chromosome 18p11. It possesses certain features of an expressed retroposon.
The centrosome, the major microtubule-organizing center (MTOC) in the animal cell, is a key determinant in the organization of the cytoplasm, in the determination of cell polarity, and in the establishment of mitotic spindle poles during the cell cycle. Centrin is a member of the calcium binding E-F hand protein superfamily present in the centrosome pericentriolar matrix.
Three separate centrin genes have been identified in human cells: centrin 1, 2, and 3. Centrin 1 shows strong amino acid homology to centrin 2 (85%), but lower homology to centrin 3 (54%) and CDC31 (50%) from the yeast S. cerevisiae. Centrin has a fundamental role in the MTOC structure and function. Phenotypic analysis of mutants in Chlamydomonas caltractin and the yeast CDC31 genes have indicated that the protein is required for proper duplication and segregation of the MTOC in the respective cells.
Three separate centrin genes have been identified in human cells: centrin 1, 2, and 3. Centrin 1 shows strong amino acid homology to centrin 2 (85%), but lower homology to centrin 3 (54%) and CDC31 (50%) from the yeast S. cerevisiae. Centrin has a fundamental role in the MTOC structure and function. Phenotypic analysis of mutants in Chlamydomonas caltractin and the yeast CDC31 genes have indicated that the protein is required for proper duplication and segregation of the MTOC in the respective cells.
Immunogen
synthetic peptide corresponding to the C-terminus of human centrin 1 (amino acids 157-172). The sequence is highly conserved in centrin 1 of many species, e.g. mouse, Drosophila, and Xenopus. It is also found in human and mouse centrin 2, but is not found in centrin 3.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Not finding the right product?
Try our Product Selector Tool.
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Asterless is a scaffold for the onset of centriole assembly
Dzhindzhev NS, et al.
Nature, 467(7316), 714-718 (2010)
M E Lachowicz-Scroggins et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 47(12), 1534-1545 (2017-08-24)
Bronchial epithelial goblet cell metaplasia (GCM) with hyperplasia is a prominent feature of asthma, but the effects of treatment with corticosteroids alone or in combination with a long-acting β2 -adrenergic receptor agonist (LABA) on GCM in the bronchial epithelium are
Yuki Yoshino et al.
Journal of cell science, 133(17) (2020-08-14)
Breast cancer gene 1 (BRCA1) contributes to the regulation of centrosome number. We previously identified receptor for activated C kinase 1 (RACK1) as a BRCA1-interacting partner. RACK1, a scaffold protein that interacts with multiple proteins through its seven WD40 domains
Clustering phenotype populations by genome-wide RNAi and multiparametric imaging
Fuchs F, et al.
Molecular Systems Biology, 6(1) (2010)
Interleukin-13-Induced Mucous Metaplasia Increases Susceptibility of Human Airway Epithelium to Rhinovirus Infection
Lachowicz-SME, et al.
American Journal of Respiratory Cell and Molecular Biology (2012)
Related Content
Instructions
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service