C7275
Concanavalin A from Canavalia ensiformis (Jack bean)
Type V, lyophilized powder
Synonym(s):
Con A
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About This Item
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type
Type V
form
lyophilized powder
potency
≤64 μg per mL agglutination activity
impurities
Carbohydrate, essentially free
salt, essentially free
≤0.16 wt. % Ca
≤0.23 wt. % Mn
storage temp.
−20°C
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Biochem/physiol Actions
Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.
Quality
Highly purified.
Preparation Note
Produced from whole Jack beans (J0250) using the method of Sophianopoulos.
Analysis Note
Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca2+ and Mn2+ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Guanbin Gao et al.
Traffic (Copenhagen, Denmark), 21(3), 274-296 (2019-12-29)
Protein retention and the transport of proteins and lipids into and out of the Golgi is intimately linked to the biogenesis and homeostasis of this sorting hub of eukaryotic cells. Of particular importance are membrane proteins that mediate membrane fusion
A J Sophianopoulos et al.
Preparative biochemistry, 11(4), 413-435 (1981-01-01)
Concanavalin A (Con A), obtained either commercially or by affinity chromatography, was further purified by incubating at 6-8 hr at pH 3.0-3.2 in 1 M NaCl, 0.08 M glycine and 3 mM each Ca2+ and Mn+2, heat treating at 45
Yeo Reum Park et al.
Journal of microbiology and biotechnology, 28(12), 2106-2112 (2018-11-02)
Concanavalin A (ConA) interacts with carbohydrates as a lectin, and recent reports proposed its application for detecting a diversity of viruses and pathogens. Structural studies have detailed the interaction between ConA and carbohydrates and the metal coordination environment with manganese
E Eich et al.
The Journal of antibiotics, 39(6), 804-812 (1986-06-01)
The cytostatic potential of twenty antibiotic agroclavines has been examined in the L5178y mouse lymphoma cell system. Twelve of these compounds are described for the first time. It is shown that the substituent at N-1 of agroclavine is very important
Gustavo Vasen et al.
Communicative & integrative biology, 13(1), 128-139 (2020-10-06)
Chemotactic/chemotropic cells follow accurately the direction of gradients of regulatory molecules. Many G-protein-coupled receptors (GPCR) function as chemoattractant receptors to guide polarized responses. In "a" mating type yeast, the GPCR Ste2 senses the α-cell's pheromone. Previously, phosphorylation and trafficking of
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