C7055
Monoclonal Anti-Calmodulin antibody produced in mouse
clone 2D1+6D4+1F11, ascites fluid
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About This Item
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
2D1+6D4+1F11, monoclonal
Application:
ARR, WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
2D1+6D4+1F11, monoclonal
contains
15 mM sodium azide as preservative
species reactivity
Dictyostelium discoideum, bovine, rat, chicken
technique(s)
microarray: suitable, western blot: 1:100 using a bovine brain calmodulin preparation
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
rat ... Calm1(24242)
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Immunogen
A preparation of purified calmodulin from Dictyostelium discoideum conjugated to KLH.
Application
Monoclonal Anti-Calmodulin antibody produced in mouse is suitable for microarray and western blotting at a dilution of 1:100 using a bovine brain calmodulin preparation.
Biochem/physiol Actions
These antibodies are directed against different epitopes within the calmodulin molecule.
Calmodulin 1 is a protein encoded by the CALM1 gene in humans. It is one of the most well characterized proteins and is used as a model system for calcium binding and large-scale protein conformational changes. Acts as a sensor protein that takes part in calcium-dependent signaling, regulating processes like growth, differentiation, proliferation and motility. It binds calcium ions during induction of intracellular signaling and is involved in silencing of calcium signal through activation of plasma membrane Ca2+-ATPase (directly) or SERCA pump (indirectly). Calmodulin may affect various channels like voltage gated calcium channels (VGCCs), transient receptor potential channels (TRPCs), NMDA receptors and calcium channels dependent on cyclic nucleotides or in endoplasmic reticulum.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
Regulatory Information
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Petri Kursula
Acta crystallographica. Section D, Biological crystallography, 70(Pt 1), 24-30 (2014-01-15)
Calmodulin is one of the most well characterized proteins and a widely used model system for calcium binding and large-scale protein conformational changes. Its long central helix is usually cut in half when a target peptide is bound. Here, two
Elzbieta Rebas et al.
Postepy biochemii, 58(4), 393-402 (2012-01-01)
Calmodulin (CaM) is a sensor protein, which takes part in calcium-dependent signaling, regulating processes like growth, differentiation, proliferation and motility. Calmodulin binds calcium ions during induction of intracellular signaling. It is also involved in silencing of calcium signal through activation
Aline Domínguez-Alonso et al.
International journal of molecular sciences, 16(1), 1907-1927 (2015-01-21)
Melatonin (MEL), the main product synthesized by the pineal gland, stimulates early and late stages of neurodevelopment in the adult brain. MEL increases dendrite length, thickness and complexity in the hilar and mossy neurons of hippocampus. Dendrite formation involves activation
Jesús Argueta et al.
International journal of molecular sciences, 23(5) (2022-03-11)
Melatonin (MEL) is a pleiotropic indolamine that reaches multiple intracellular targets. Among these, MEL binds to calmodulin (CaM) with high affinity. In presence of Ca2+, CaM binds to CaM-dependent kinase II (CaMKII). The Ca2+-CaM/CaMKII pathway regulates a myriad of brain
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