C5813
Complement factor H from human plasma
1 mg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)
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About This Item
Form:
liquid
Assay:
≥90% (SDS-PAGE)
Biological source:
human plasma
Product Name
Complement factor H from human plasma, 1 mg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)
biological source
human plasma
assay
≥90% (SDS-PAGE)
form
liquid
concentration
1 mg/mL in PBS, pH 7.2
technique(s)
activity assay: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... CFH(3075)
Application
Complement factor H (CFH) is a plasma regulator of the complement protein C3b in the alternative pathway of the complement system. Research has shown that binding of CFH is important for pathogenesis of group A streptococcus (GAS), and inhibition of this binding may be an effective management of GAS infections.
Biochem/physiol Actions
C3b-binding protein which regulates the formation and function of complement C3 and C5 convertases.
Complement factor H plays an essential role in the homeostasis of the complement system and in preventing collateral damage to bystander cells and tissues by complement activation.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Other Notes
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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Acquisition of Complement Factor H Is Important for Pathogenesis of Streptococcus pyogenes Infections: Evidence from Bacterial In Vitro Survival and Human Genetic Association.
Haapasalo K., et al.
Journal of Immunology (2011)
Johanna M Seddon et al.
JAMA ophthalmology, 131(4), 448-455 (2013-02-16)
Risk score models predicting the progression of age-related macular degeneration (AMD) to its advanced forms may be useful for targeting high-risk individuals for lifestyle changes that reduce risk for AMD progression, helping with differential diagnosis of AMD and its subtypes
Valentina Cipriani et al.
Nature communications, 11(1), 778-778 (2020-02-09)
Age-related macular degeneration (AMD) is a leading cause of blindness. Genetic variants at the chromosome 1q31.3 encompassing the complement factor H (CFH, FH) and CFH related genes (CFHR1-5) are major determinants of AMD susceptibility, but their molecular consequences remain unclear.
A Massart et al.
Acta clinica Belgica, 68(1), 9-14 (2013-05-01)
Atypical haemolytic uraemic syndrome (aHUS) results from uncontrolled complement system activation. Complement factor H gene mutations are common causes of aHUS. Plasmatherapy, including plasma infusions and/or plasma exchanges, has been tried in this setting with various successes. At present, we
Complement Factor H-ligand interactions: Self-association, multivalency and dissociation constants.
Perkins SJ., et al.
Immunobiol. (2011)
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