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Merck
CN

C5624

Cryptotanshinone

≥98% (HPLC)

Synonym(s):

1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione, Cryptotanshinon, Tanshinone c

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About This Item

Empirical Formula (Hill Notation):
C19H20O3
CAS Number:
35825-57-1
Molecular Weight:
296.36
NACRES:
NA.77
PubChem Substance ID:
329775097
UNSPSC Code:
12352200
MDL number:
MFCD07636810

Key Documents

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Product Name

Cryptotanshinone, ≥98% (HPLC)

InChI key

GVKKJJOMQCNPGB-JTQLQIEISA-N

SMILES string

C[C@H]1COC2=C1C(=O)C(=O)c3c4CCCC(C)(C)c4ccc23

InChI

1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -80 to -99°, c = 0.5 in chloroform-d

storage condition

desiccated
protect from light

color

orange-brown

solubility

DMSO: ≥5 mg/mL

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cryptotanshinone is a specific STAT3 inhibitor. It prevents STAT3 dimerization.
Cryptotanshinone is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Recently it was discovered that the compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. Previously, it was reported that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression. In traditional oriental medicine dried roots of Salvia Miltiorrhiza Bunge (Danshen) have commonly been used for the treatment of circulatory disorders, liver disease, coronary heart disease, hepatitis, and chronic renal failure.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000220173
0000220174
0000215880
0000220173
0000220174

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Jia-Hau Yen et al.
Molecular therapy oncolytics, 26, 158-174 (2022-07-22)
Dampening tumor growth by converting tumor-associated macrophages (TAMs) from M2/repair-types to M1/kill-types is of high interest. Here, we show that cryptotanshinone (CPT) can function as an antitumor immune modulator that switches TAMs from an M2 to an M1 phenotype, leading
Yongpeng Zhang et al.
Drug development research, 82(4), 581-588 (2020-12-20)
Coronary microembolization (CME) is a prevalent cardiovascular disease, especially nowadays when percutaneous coronary intervention is widely applied. However, neither cardio-protective agents nor devices for distal protection could effectively prevent the occurrence of CME. Therefore, we aimed to develop a new
Zhiyuan Lu et al.
Molecular biology reports, 51(1), 436-436 (2024-03-23)
Elevated levels of adipokine chemerin have been identified in oral squamous cell carcinoma (OSCC) and found to be associated with metastasis to the cervical lymph nodes. The underlying mechanism through which chemerin affects OSCC progression is unclear. The aims of
Chunlong Ma et al.
ACS pharmacology & translational science, 5(2), 102-109 (2022-02-19)
SARS-CoV-2 encodes two viral cysteine proteases, the main protease (Mpro) and the papain-like protease (PLpro), both of which are validated antiviral drug targets. PLpro is involved in the cleavage of viral polyproteins as well as immune modulation by removing ubiquitin
In-Ja Park et al.
Apoptosis : an international journal on programmed cell death, 17(3), 248-257 (2011-11-25)
The endoplasmic reticulum (ER) is a central organelle in eukaryotic cells that functions in protein synthesis and maturation, and also functions as a calcium storage organelle. Perturbation of ER functions leads to ER stress, which has been previously associated with
View All Related Papers

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