C5499
Cytochrome c Oxidase from bovine heart
5 mg protein/mL
Synonym(s):
EC 1.9.3.1, Ferrocytochrome-c:oxygen oxidoreductase, Complex IV
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About This Item
CAS Number:
UNSPSC Code:
12352204
NACRES:
NA.32
EC Number:
232-586-0
MDL number:
Product Name
Cytochrome c Oxidase from bovine heart, 5 mg protein/mL
biological source
bovine heart
form
buffered aqueous solution
specific activity
≥20 units/mg protein
mol wt
300-350 kDa by gel filtration
greener alternative product characteristics
Waste Prevention
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.
sustainability
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concentration
5 mg protein/mL
greener alternative category
, Enabling
shipped in
dry ice
storage temp.
−20°C
Quality Level
Related Categories
Other Notes
One unit of cytochrome c oxidase will oxidize 1.0 μmole of ferrocytochrome c per min. at 25 °C at pH 6.0.
Application
Cytochrome c Oxidase (CcO) from bovine heart has been used:
- to study the effect of oxidized glutathione (GSSG) on the number of total free cysteines
- in a histochemical assay to measure CcO activity in tissue sections
- to study the redox reactions of cytochrome c in isolated mitochondria exposed to blue or red lasers using resonance Raman spectroscopy
Biochem/physiol Actions
Cytochrome c oxidase is the principal terminal oxidase of high oxygen affinity in the aerobic metabolism of all animals, plants, yeasts and some bacteria.
Cytochrome c oxidase is the principal terminal oxidase of high oxygen affinity in the aerobic metabolism of all animals, plants, yeasts and some bacteria. It is present in the mitochondria of the more highly developed cells and in the cytoplasmic membrane of bacteria. Cytochrome c oxidase catalyses the electron transfer from cytochrome c to O2. This electron-transfer process produces a proton gradient across the membrane, which in turn drives the production of ATP. This enzyme is unique in providing energy for the cell bycoupling the electron transport through the cytochrome chain with the process of oxidative phosphorylation.
General description
Research area: Cell cycle
Cytochrome c oxidase contains 13 subunits, encoded by mitochondrial genes and nuclear genome. It is comprised of two heme groups (Fea and Fea3) and two copper centers, CuA and CuB.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency and waste prevention when used in biofuel cell research. For more information see the article in biofiles.
Cytochrome c oxidase contains 13 subunits, encoded by mitochondrial genes and nuclear genome. It is comprised of two heme groups (Fea and Fea3) and two copper centers, CuA and CuB.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency and waste prevention when used in biofuel cell research. For more information see the article in biofiles.
Physical form
Supplied as a solution in 25 mM Tris-HCl buffer, pH 7.8, 5 mM EDTA, and 39 mM n-dodecyl β·-D-maltoside.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
动植物源性产品
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Claudia R Oliva et al.
Oncotarget, 8(23), 37568-37583 (2017-04-30)
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Reply to Giamogante et al.: The effect of low cyanide on O2 consumption is best observed in physiological, rather than reductionist, systems.
Karim Zuhra et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(39) (2021-09-22)
Cytochrome c Oxidase Dysfunction in Oxidative Stress
Srinivasan S & Avadhani NG
Free Radical Biology & Medicine (2013)
Sze Kiat Sim et al.
Turkish neurosurgery, 25(4), 617-624 (2015-08-06)
This study evaluated the neuroprotective effect of intrathecally infused paclitaxel in the prevention of motoneuron death and mitochondrial dysfunction following brachial plexus avulsion injury. Brachial root avulsion injury was induced in Sprague-Dawley rats. The Paclitaxel treatment group (n = 32)
Claudia R Oliva et al.
The Journal of biological chemistry, 291(46), 24188-24199 (2016-09-30)
The enzyme cytochrome c oxidase (CcO) or complex IV (EC 1.9.3.1) is a large transmembrane protein complex that serves as the last enzyme in the respiratory electron transport chain of eukaryotic mitochondria. CcO promotes the switch from glycolytic to oxidative
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