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C5490

C75

Name: C75
Brand: SIGMA

≥98% (HPLC), fatty acid synthase (FAS) inhibitor of, powder

Synonym(s):

4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₂₂O₄

CAS Number:

218137-86-1

Molecular Weight:

254.32

UNSPSC Code:

41121801

PubChem Substance ID:

24892789

NACRES:

NA.77

MDL number:

MFCD03426157

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Product Name

C75, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

CCCCCCCCC1OC(=O)C(=C)C1C(O)=O

InChI

1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)

InChI key

VCWLZDVWHQVAJU-UHFFFAOYSA-N

Description

Application

C75 has been used:

as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin
as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)
as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide

Biochem/physiol Actions

C75 helps to increase the cancer‐killing capability of ionizing radiation.

C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Fatty Acid Synthesis in Cancer Cells

Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.

Discover Bioactive Small Molecules for Lipid Signaling Research

Starvation causes female-to-male sex reversal through lipid metabolism in the teleost fish, medaka (Olyzias latipes).

Yuta Sakae et al.

Biology open, 9(4) (2020-04-09)

The teleost fish, medaka (Oryzias latipes), employs the XX/XY genetic sex determination system. We show here that the phenotypic sex of medaka is affected by changes in lipid metabolism. Medaka larvae subjected to 5 days of starvation underwent female-to-male sex reversal.

Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b

Wahdan-Alaswad RS, et al.

Hormones & Cancer, 5(6), 374-389 (2014)

Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence

Kim YM, et al.

Test, 285(38), 29069-29077 (2010)

View All Related Papers

Global Trade Item Number

SKU	GTIN
C5490-25MG	04061833269985
C5490-5MG	04061833502198