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Safety Information

C5423

Sigma-Aldrich

Clenbuterol hydrochloride

≥95% (TLC), powder, β2-adrenoceptor agonist

Synonym(s):

4-Amino-α-(t-butylaminomethyl)-3,5-dichlorobenzyl alcohol hydrochloride

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10 μG
¥3,703.16

About This Item

Empirical Formula (Hill Notation):
C12H18Cl2N2O · HCl
CAS Number:
21898-19-1
Molecular Weight:
313.65
EC Number:
244-643-7
MDL number:
MFCD00083280
UNSPSC Code:
12352200
PubChem Substance ID:
24892782
NACRES:
NA.77

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Product Name

Clenbuterol hydrochloride, ≥95%

Quality Level

200

Assay

≥95%

form

powder

drug control

Home Office Schedule 4.2

storage temp.

2-8°C

SMILES string

Cl.CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1

InChI

1S/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H

InChI key

OPXKTCUYRHXSBK-UHFFFAOYSA-N

Gene Information

human ... ADRB2(154)

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Show Differences

1 of 4

This Item
SRP2056SRP2045SRP2139
PPAR γ, ligand binding domain (204-477), GST tagged human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

SRP2140

PPAR γ, ligand binding domain (204-477), GST tagged human

PPARγ, ligand binding domain (165-441) human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

SRP2056

PPARγ, ligand binding domain (165-441) human

PPAR， γ 人 recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

SRP2045

PPAR， γ 人

PPAR δ, ligand binding domain (165-441), GST tagged human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

SRP2139

PPAR δ, ligand binding domain (165-441), GST tagged human

biological source

human

biological source

human

biological source

human

biological source

human

assay

≥80% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

concentration

450 μg/mL

concentration

350 μg/mL

concentration

500 μg/mL

concentration

300 μg/mL

form

frozen liquid

form

frozen liquid

form

frozen liquid

form

frozen liquid

mol wt

~57.8 kDa

mol wt

~33.6 kDa

mol wt

~60 kDa

mol wt

~58.2 kDa

Application

Clenbuterol hydrochloride has been used:
  • as an agonist for β-adrenergic receptor (β-AR) from chick skeletal muscle[1]
  • to induce hypertrophic effects in masseter, digastric, and temporalis muscles of rat[2]
  • as a reference β-agonist standard in tandem mass spectrometry(MS-MS)[3]

Biochem/physiol Actions

Clenbuterol hydrochloride is a β2-adrenoceptor agonist and bronchodilator. It is effective in improving peak expiratory flow rate (PEFR) in asthma patients.[4] Clenbuterol is also a performance-enhancing drug as it stimulates the central nervous system and improves oxygen transport. Clenbuterol elicits cardio protective functionality in patients with dilated cardiomyopathy.[5]

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H351,H360FD

Hazard Classifications

Carc. 2 - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCK9701
    BCCK9700
    BCCB5150
    BCBQ2163V
    BCBQ1350V

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    A trial of clenbuterol in bronchial asthma.
    Anderson G and Wilkins E
    Thorax, 32(6), 717-719 (1977)
    C A Izeboud et al.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 48(9), 497-502 (1999-10-16)
    To investigate the suppressive effects of the beta-agonist clenbuterol on the release of TNF-alpha and IL-6 in a lipopolysaccharide (LPS)-model of inflammation, both in vitro and in vivo. Human U-937 cell line (monocyte-derived macrophages), and male Wistar rats (200-250 g).
    Jelka Pleadin et al.
    Meat science, 86(3), 733-737 (2010-07-30)
    The aim of this study was to determine the level of clenbuterol residues in muscle tissue of pigs after repeat administration in a growth-promoting dose. An anabolic dose of clenbuterol (20 μg/kg body mass per day) was administered orally to
    Vipin Arora et al.
    Molecular pain, 17, 1744806921997206-1744806921997206 (2021-04-09)
    Beta 2 adrenergic receptor (β2 AR) activation in the central and peripheral nervous system has been implicated in nociceptive processing in acute and chronic pain settings with anti-inflammatory and anti-allodynic effects of β2-AR mimetics reported in several pain states. In
    beta2-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats
    Zhang Q, et al.
    British Journal of Pharmacology, 160(6), 1561-1572 (2010)
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