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Merck
CN

C5259

Carbamyl-β-methylcholine chloride

≥99% (TLC), crystalline

Synonym(s):

Bethanechol chloride

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About This Item

Linear Formula:
C7H17N2O2Cl
CAS Number:
590-63-6
Molecular Weight:
196.68
NACRES:
NA.25
PubChem Substance ID:
24277823
UNSPSC Code:
41116107
EC Number:
209-686-8
MDL number:
MFCD00055224
Assay:
≥99% (TLC)
Form:
crystalline
Quality level:
100

Key Documents

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InChI key

AIRHOJQHGLTTTB-UHFFFAOYSA-N

InChI

1S/C7H17N2O2.ClH/c1-6(11-7(8)10)5-9(2,3)4;/h6H,5H2,1-4H3,(H2,8,10);1H

SMILES string

Cl.CC(C[N](C)(C)C)OC(N)=O

assay

≥99% (TLC)

form

crystalline

color

white

solubility

H2O: 1.7 g/mL (stable for several days at 4°C.), ethanol: 80 mg/mL (stable for several days at 4°C.)

storage temp.

2-8°C

Quality Level

100

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General description

Muscarinic acetylcholine receptor agonist that is not a substrate for acetylcholinesterase.

Application

Carbamyl-β-methylcholine chloride has been used in western blotting and bactericidal assay. It has also been used in concentration-response studies with isolated atrial preparation.

Biochem/physiol Actions

Carbamyl-β-methylcholine has a selective action on urinary bladder and intestine. It induces smooth muscle tension in the bladder. Its main function is to induce detrusor muscle action, mediated by postganglionic parasympathetic effector cells. Nausea, flushing, sweating, abdominal cramps are some of the side effect caused by carbamyl-β-methylcholine.

Disclaimer

Hygroscopic.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV2701
MKCG7600
MKCF1378
MKBX1915V
MKBQ9916V

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Ana Beatriz Albino de Almeida et al.
Journal of medicinal food, 15(4), 378-383 (2011-12-24)
Arctium lappa L. has been used in folk medicine as a diuretic, depurative, and digestive stimulant and in dermatological conditions. The mechanisms involved in the anti-ulcerogenic activity of the sesquiterpene onopordopicrin (ONP)-enriched fraction (termed the ONP fraction), obtained from A.
Jagmohan Singh et al.
Gastroenterology, 143(5), 1308-1318 (2012-08-07)
Patients with systemic sclerosis (SSc) have impairments in gastrointestinal smooth muscle function. The disorder has been associated with circulating antibodies to cholinergic muscarinic the type-3 receptor (M(3)-R). We investigated whether it is possible to neutralize these antibodies with pooled human
Adult and Pediatric Urology, 1, 1127-1127 (2002)
Munenori Nagao et al.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 16(2), 334-343 (2011-11-08)
Our aim was to determine mechanisms of action of the gasotransmitter hydrogen sulfide (H(2)S) on contractile activity in circular muscle of rat jejunum. Jejunal circular muscle strips were prepared to measure isometric contractions. Effects of sodium hydrosulfide (NaHS), a H(2)S
Y Koga et al.
European journal of pharmacology, 220(2-3), 141-146 (1992-09-22)
To seek evidence for the involvement of acetylcholinesterase activity in the modulatory influence of the airway epithelium, we examined responses to acetylcholine (ACh), bethanechol, histamine or KCl in isolated epithelium-intact and epithelium-denuded guinea-pig trachealis preparations. The concentration-response curves to ACh
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