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C5135

Sigma-Aldrich

Castor Oil, Ethoxylated

pH range 6.0-8.0

Synonym(s):

Cremophor® EL, EL, Macrogolglycerol ricinoleate, PEG-35 castor oil, Polyoxyl-35 castor oil

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About This Item

CAS Number:
61791-12-6
MDL number:
MFCD00130879
UNSPSC Code:
12161902
NACRES:
NA.25

description

non-ionic

Quality Level

200

form

liquid

mol wt

~2500 g/mol

pH range

6.0-8.0

HLB

12 - 14

application(s)

sample preservation

InChI

1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8)

InChI key

JMNCUXPHXKHBPY-UHFFFAOYSA-N

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General description

Castor Oil, Ethoxylated is a nonionic solubilizer and emulsifier made by reacting castor oil with ethylene oxide. It is a pale yellow oily liquid that is clear at temperatures above 26°C. It has a faint but characteristic odour.
Castor Oil, Ethoxylated is polyethylene oxide surfactant and is viscous in nature. It has a hydrophobic-lipophilic balance value in the range of 12-14.

Application

Castor Oil, Ethoxylated has been used as a detergent to improve the solubility of dye and to increase the transmembrane permeation. It has been used as a vehicle for drug/stimulant delivery in cells.

Biochem/physiol Actions

Castor Oil, Ethoxylated is used in lipid-based formulations for drugs and solubilization of cosmetics. Castor Oil, Ethoxylated is suitable for the production of semi-solid and liquid formulations of water-insoluble actives and other hydrophobic compounds. Due to its emulsification functionality, it finds application in biological membrane- based drug transport studies.

Other Notes

A derivative of castor oil and ethylene oxide.

Legal Information

Cremophor is a registered trademark of BASF SE

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What solvents can I use to prepare a solution of Cremophor EL (Product No. C5135)? Or is it already in solution?

    Cremophor EL is a neat liquid, sold by weight. It is not already in solution. It is soluble in water; note that the solubility in water actually decreases with an increase in temperature. It is also soluble in many organic solvents, such as ethanol, isopropyl alcohol, chloroform and others.

  6. What is the hydrophile-lipophile balance (HLB) for Cremophor EL (Product No. C5135)?

    The manufacturer (BASF) reports an HLB value of between 12 and 14 for Cremophor EL (Product No. C5135).

  7. What is the molecular weight of Cremophor EL (Product No. C5135)?

    The manufacturer (BASF) reports a molecular weight of approximately 2500 for Cremophor EL (Product No. C5135).

  8. How can Cremophor EL (Product No. C5135) be sterilized?

    The manufacturer (BASF) recommends that it be sterilized by heating in an autoclave for 30 minutes at 120°C. It may acquire a somewhat deeper color. Either the neat material or neutral aqueous solutions may be autoclaved.

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