C4650
Cholestyramine resin
Synonym(s):
Colestyramine
assay
13-17% chloride basis (dried substance)
form
powder
technique(s)
activity assay: suitable
matrix
polystyrene/divinylbenzene
pH
4—6
capacity
~1.0 meq/g(dry)
Quality Level
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Application
Cholestyramine resin has been used:
- as a diet supplement to study the bile acid pool size and fecal bile acid output in mice
- to alter the bile acid (BA) levels and study its effect on liver fibrosis development in wild type (WT), fibroblast growth factor 15 (Fgf15)−/−, and Fgf15 transgenic (TG) mice
- in in vitro digestion process to study the capacity of the fractions for binding bile acid (BA)
Cholestyramine resin is used in protein chromatography, ion exchange chromatography and anion exchange media. Cholestyramine has been used to study the relief of postcholecystectomy diarrhea, the management of intractable cholestatic pruritus and obesity.
Biochem/physiol Actions
Cholestyramine is a cationic exchange resin polymer. This resin is a bile acid sequestrant that interchanges chloride anions for bile acids of the small intestine lumen, leading to excretion of bile acids in the feces and reduced levels of serum bile acid. Cholestyramine is used to treat primary hypercholesterolemia. The resin induces dose-dependent reduction of low-density lipid (LDL) cholesterol. It ameliorates the risk of coronary artery disease.
Other Notes
Quartenary ammonium functional groups attached to cross-linked polystyrene
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Ellin Simon et al.
Journal of anxiety disorders, 26(2), 287-296 (2012-01-17)
In this study, the cost-effectiveness of three indicated anxiety prevention strategies was examined from a societal perspective. Children (aged 8-12) were recruited via primary schools, selecting children scoring as high-anxious on an anxiety screening questionnaire. Participating children and their parents
Shahram Ala et al.
World journal of surgery, 37(3), 657-662 (2012-12-12)
The aim of the present study was to evaluate the efficacy of cholestyramine ointment (15 %) in reducing postoperative pain at rest and during defecation after open hemorrhoidectomy. A total of 91 patients with third and fourth degree hemorrhoids undergoing
Noémie Péan et al.
Hepatology (Baltimore, Md.), 58(4), 1451-1460 (2013-05-21)
Many regulatory pathways are involved in liver regeneration after partial hepatectomy (PH) to initiate growth, protect liver cells, and sustain functions of the remnant liver. Bile acids (BAs), whose levels rise in the blood early after PH, stimulate both hepatocyte
Ju-Ling Liu et al.
PLoS genetics, 8(3), e1002553-e1002553 (2012-03-23)
Mammalian bile acids (BAs) are oxidized metabolites of cholesterol whose amphiphilic properties serve in lipid and cholesterol uptake. BAs also act as hormone-like substances that regulate metabolism. The Caenorhabditis elegans clk-1 mutants sustain elevated mitochondrial oxidative stress and display a
Märta K Borghede et al.
European journal of internal medicine, 22(6), e137-e140 (2011-11-15)
The liver produces and secretes bile acids into the small intestine. In the small intestine, most of the bile acids are absorbed in the distal ileum with portal vein transportation back to the liver and resecretion (enterohepatic recycling). Increased spillover
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