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Merck
CN

C4461

Colistin sulfate salt

≥19,000 IU/mg

Synonym(s):

Polymyxin E

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About This Item

CAS Number:
1264-72-8
UNSPSC Code:
51102829
eCl@ss:
34050906
EC Number:
215-034-3
NACRES:
NA.85
MDL number:
MFCD00146495

Key Documents

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Product Name

Colistin sulfate salt, ≥19,000 IU/mg

SMILES string

[S](=O)(=O)(O)O.N1[C@H](C(=O)NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C1=O)CCN)CCN)CC(C)C)CC(C)C)CCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCC(CC)C)CCN)[C@H](O)C)CCN)[C@H](O)C

InChI

1S/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1

InChI key

ZJIWRHLZXQPFAD-LRYSGCCDSA-N

Quality Level

200

biological source

microbial

assay

≥19000 IU/mg ((EP, dried substance))

form

powder

specific activity

≥19,000 IU/mg

storage condition

(Tightly closed. Dry.)

concentration

≤ 100%

technique(s)

microbe id | susceptibility testing: suitable

color

white to off-white

suitability

suitable for microbiological tests

antibiotic activity spectrum

Gram-negative bacteria

application(s)

microbiology

mode of action

cell membrane | interferes

storage temp.

2-8°C

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Analysis Note

Freely soluble in water, practically insoluble in acetone and in ethanol (96%)

Application

Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii . It has been used to study hephrotoxicity in the rat kidney , and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa .

Biochem/physiol Actions

Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH .

General description

Chemical structure: peptide

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000521852
0000521852
0000505843
0000505843
0000505842

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Lisa M Leung et al.
Journal of clinical microbiology, 57(3) (2018-12-21)
Acinetobacter baumannii is a prevalent nosocomial pathogen with a high incidence of multidrug resistance. Treatment of infections due to this organism with colistin, a last-resort antibiotic of the polymyxin class, can result in the emergence of colistin-resistant strains. Colistin resistance
Xingchen Bian et al.
International journal of antimicrobial agents, 57(2), 106271-106271 (2020-12-23)
Polymyxin-based combination therapy is often used to treat carbapenem-resistant Acinetobacter baumannii (A. baumannii) infections. Although sulbactam is intrinsically active against A. baumannii, few studies have investigated colistin/sulbactam combinations against carbapenem-resistant A. baumannii. Whole genome sequencing was undertaken on eight carbapenem-resistant (colistin-susceptible)
Ansley M Nemeth et al.
ChemMedChem, 15(2), 210-218 (2019-11-23)
Infections caused by multidrug-resistant (MDR) bacteria, particularly Gram-negative bacteria, are an escalating global health threat. Often clinicians are forced to administer the last-resort antibiotic colistin; however, colistin resistance is becoming increasingly prevalent, giving rise to the potential for a situation
Deepesh Nagarajan et al.
Science advances, 5(7), eaax1946-eaax1946 (2019-07-30)
Drug resistance is a public health concern that threatens to undermine decades of medical progress. ESKAPE pathogens cause most nosocomial infections, and are frequently resistant to carbapenem antibiotics, usually leaving tigecycline and colistin as the last treatment options. However, increasing
Peng Cui et al.
Antimicrobial agents and chemotherapy, 60(11), 6867-6871 (2016-09-08)
Persisters are small populations of quiescent bacterial cells that survive exposure to bactericidal antibiotics and are responsible for many persistent infections and posttreatment relapses. However, little is known about how to effectively kill persister bacteria. In the work presented here
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