All Photos(2)
Synonym(s):
Aptiganel hydrochloride, Cerestat, N-(3-Ethylphenyl)-N-methyl-N’-1-naphthalenylguanidine hydrochloride
Empirical Formula (Hill Notation):
C20H21N3 · HCl
CAS Number:
Molecular Weight:
339.86
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
>98% (HPLC)
form
solid
color
white
solubility
H2O: soluble 17 mg/mL
DMSO: soluble 20 mg/mL
storage temp.
2-8°C
SMILES string
Cl[H].CCc1cccc(c1)N(C)C(=N)Nc2cccc3ccccc23
InChI
1S/C20H21N3.ClH/c1-3-15-8-6-11-17(14-15)23(2)20(21)22-19-13-7-10-16-9-4-5-12-18(16)19;/h4-14H,3H2,1-2H3,(H2,21,22);1H
InChI key
CKAKVKWRMCAYJD-UHFFFAOYSA-N
Biochem/physiol Actions
CNS-1102 acts as a neuroprotective agent and might exhibit therapeutic effects against acute stroke and traumatic brain injury.
Noncompetitive NMDA glutamate receptor antagonist.
Features and Benefits
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Certificates of Analysis (COA)
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K W Muir et al.
Annals of the New York Academy of Sciences, 765, 279-289 (1995-09-15)
The high affinity noncompetitive N-methyl-D-aspartate receptor antagonist CNS 1102 (aptiganel hydrochloride, Cambridge NeuroScience, Cambridge, MA.) is neuroprotective in preclinical models of stroke when administered as pretreatment or up to 60 minutes postischemia, and has potential for treatment of acute stroke
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