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C3866

Sigma-Aldrich

Anti-Calcitonin Receptor-Like Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
MFCD06798428
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

availability

not available in Japan

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 7.5 μg/mL using human arterial smooth muscle

UniProt accession no.

Q16602

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CALCRL(10203)
mouse ... Calcrl(54598)
rat ... Calcrl(25029)

Immunogen

synthetic peptide corresponding to the first extracellular loop of human calcitonin receptor-like receptor, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.

Application

Anti-Calcitonin Receptor-Like Receptor antibody produced in rabbit was used for immunocytochemistry of mouse bone marrow-derived mucosal mast cells at a dilution of 1:100.

Biochem/physiol Actions

Calcitonin receptor-like receptor (CLR) is a G protein-coupled receptor that binds receptor-activity-modifying proteins (RAMP)1, -2 and -3. CLR has been implicated in conditions such as obesity, diabetes, osteoporosis, migraine and cardiovascular disease.

Physical form

Solution in phosphate buffered saline containing ≤ 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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J W Rychter et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 23(2), e57-e68 (2010-10-23)
The parasitized or inflamed gastrointestinal mucosa shows an increase in the number of mucosal mast cells (MMC) and the density of extrinsic primary afferent nerve fibers containing the neuropeptide, calcitonin gene-related peptide (CGRP). Currently, the mode of action of CGRP
James Barwell et al.
British journal of pharmacology, 166(1), 51-65 (2011-06-09)
The calcitonin receptor (CTR) and calcitonin receptor-like receptor (CLR) are two of the 15 human family B (or Secretin-like) GPCRs. CTR and CLR are of considerable biological interest as their pharmacology is moulded by interactions with receptor activity-modifying proteins. They
Eric L Moore et al.
British journal of pharmacology, 166(1), 66-78 (2011-08-30)
The clinical effectiveness of antagonizing the calcitonin gene-related peptide (CGRP) receptor for relief of migraine pain has been clearly demonstrated, but the road to the development of these small molecule antagonists has been daunting. The key hurdle that needed to
Rikke R Hansen et al.
Pain, 157(3), 666-676 (2015-11-18)
Severe pain is a common and debilitating complication of metastatic bone cancer. Current analgesics provide insufficient pain relief and often lead to significant adverse effects. In models of cancer-induced bone pain, pathological sprouting of sensory fibers at the tumor-bone interface

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