C3635
4-Chloro-DL-phenylalanine methyl ester hydrochloride
Tryptophan hydroxylase inhibitor, powder
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About This Item
Linear Formula:
ClC6H4CH2CH(NH2)CO2CH3·HCl
CAS Number:
Molecular Weight:
250.12
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
238-024-0
MDL number:
Product Name
4-Chloro-DL-phenylalanine methyl ester hydrochloride,
InChI key
GCBCWTWQAFLKJG-UHFFFAOYSA-N
InChI
1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H
SMILES string
Cl.COC(=O)C(N)Cc1ccc(Cl)cc1
form
powder
mp
186-189 °C (lit.)
storage temp.
−20°C
Quality Level
Gene Information
human ... TPH1(7166), TPH2(121278)
Related Categories
General description
4-Chloro-DL-phenylalanine methyl ester hydrochloride stimulates glucose intolerance in pregnant mice. Studies have shown that 4-Chloro-DL-phenylalanine methyl ester hydrochloride is associated with cognitive defects in rodents.
Application
4-Chloro-DL-phenylalanine methyl ester hydrochloride has been used to induce 5-hydroxytryptamine (5-HT) depletion in rats.
Biochem/physiol Actions
Tryptophan hydroxylase inhibitor. Crosses blood brain barrier better than p−chlorophenylalanine.
Tryptophan hydroxylase inhibitor.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism
du Jardin KG, et al.
European Neuropsychopharmacology, 24(1), 160-171 (2014)
Serotonin regulates pancreatic beta cell mass during pregnancy
Kim H, et al.
Nature Medicine, 16(7), 804-804 (2010)
Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus
Kornum BR, et al.
Brain Research, 1073, 262-268 (2006)
K Linnet et al.
Brain research, 697(1-2), 251-253 (1995-10-30)
In order to study the impact of serotonin depletion on gene expression of the serotonin transporter (5-HTt) we measured 5-HTt mRNA levels by Northern blot in rats treated with p-chlorophenylalanine methyl ester (PCPA) for 10 days. Six rats received PCPA
P Chen et al.
Pancreas, 13(2), 147-153 (1996-08-01)
The biological significance and function of pancreatitis-associated protein (PAP), identified in 1984 as a new secretory protein appearing during pancreatitis, remain to be elucidated. The purpose of this study was to evaluate the presence of PAP in pancreatic tissue upon
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