C3144
Coenzyme A sodium salt hydrate
cofactor for acyl transfer
Synonym(s):
CoA Na2
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About This Item
Empirical Formula (Hill Notation):
C21H36N7O16P3S · xNa+ · yH2O
CAS Number:
Molecular Weight:
767.53 (anhydrous free acid basis)
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
description
cofactor for acyl transfer
Quality Level
Assay
≥85% (spectrophotometric assay)
form
powder
solubility
H2O: soluble 50 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
SMILES string
[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
InChI key
SYTRWOCXZXQBPW-CLVRNSBASA-M
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General description
Coenzyme A (CoA) is an essential cofactor in living systems and is synthesized from pantothenic acid (vitamin B5), The CoA levels in mitochondria and peroxisomes correspond to 2-5 mM and 0.7 mM, respectively. Cytosolic CoA is in the range of 0.05 mM to 0.14 mM
Application
Coenzyme A is suitable for use in:
- gylcerolipid biosynthesis in porcine adipose tissue
- an assay to measure the level of Alpha-methylacyl-CoA racemase (AMACR) in human blood samples using a nanoparticle electrochemical biosensor
- chloramphenicol acetyltransferase (CAT) assay
- the synthesis of palmitoyl-CoA, which is required for palmitoylation and activation of proteins for regulated membrane fusion
Biochem/physiol Actions
Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes. In the presence of CoASH, organic carboxylic acids form acyl-CoA thioesters, which facilitates enzyme recognition. The acyl-CoA formed from xenobiotic carboxylic acids can add to the compound′s toxicity, which can lead to cellular metabolic dysfunction. It is involved in the oxidation of pyruvate in the Kreb′s cycle. CoA is needed for metabolic events. The bacterial CoA pathway is targeted for antimicrobial development. It mediates acyl group transfer and carbonyl activation. The CoA and its thioester levels are crucial for cellular homeostasis. CoA is also involved in regulating platelet aggregation and vasoconstriction. It acts as an essential cofactor in enzymatic acetyl transfer reactions.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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D C Rule et al.
Journal of animal science, 67(2), 364-373 (1989-02-01)
To compare genetic differences in glycerolipid biosynthesis, rates were determined in s.c. adipose tissue of lean and obese pigs at 28, 60 and 110 d of age. To compare depot-specific differences, glycerolipid biosynthetic rates were determined in outer s.c., middle
Biosynthesis of pantothenic acid and coenzyme A
LEONARDI R and JACKOWSKI S
Ecosal plus, 2(2) (2007)
Signalling functions of coenzyme A and its derivatives in mammalian cells
Davaapil H, et al.
Biochemical Society Transactions, 42(4), 1056-1062 (2014)
Po-Yuan Lin et al.
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Although still commonly used in clinical practice to screen and diagnose prostate cancer, there are numerous weaknesses of prostate-specific antigen (PSA) testing, including lack of specificity and the inability to distinguish between aggressive and indolent cancers. A promising prostate cancer
Christoph Matti et al.
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Chemokines are essential for guiding cell migration. Atypical chemokine receptors (ACKRs) contribute to the cell migration process by binding, internalizing and degrading local chemokines, which enables the formation of confined gradients. ACKRs are heptahelical membrane spanning molecules structurally related to
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