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Merck
CN

C2969

Monoclonal Anti-I-CAM-1 (CD54) antibody produced in mouse

clone 8.4A6, purified immunoglobulin

Synonym(s):

Monoclonal Anti-CD54, Anti-I-CAM-1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00240668
Conjugate:
unconjugated
Clone:
8.4A6, monoclonal
Application:
ELISA (i), FACS, ICC, IHC (f)
Citations:
1

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

8.4A6, monoclonal

mol wt

antigen 85-110 kDa

species reactivity

human, monkey

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry (frozen sections): suitable, indirect ELISA: suitable

isotype

IgG1

UniProt accession no.

P05362

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ICAM1(3383)

Related Categories

General description

CD54 (I-CAM-1) is a glycoprotein involved in mediation of intercellular adhesion. CD54 is expressed by activated endothelial cells and is also detected on cells of many other lineages and in plasma.

Immunogen

TNF-α activated human endothelial cells.

Biochem/physiol Actions

The antibody recognizes the human CD54 (I-CAM-1) surface antigen by flow cytometry, ELISA, immunocytochemistry, and immunohistochemistry. It inhibits human leukocyte adhesion to activated endothelial cells and stimulates homotypic aggregation of SKW3 cells. The epitope recognized by the antibody is localized in domain D2 of the CD54 molecule.
5th Workshop: code no. S 100

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4.

Preparation Note

Product filtered through a 0.2 μm filter

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
073M4791V
038K4797
086K4774
026K4835
101K4817

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Lanlan Tang et al.
Oncotarget, 8(16), 27314-27327 (2017-04-14)
Differentiation therapy based on all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) for the treatment of acute promyelocytic leukemia (APL) is complicated by the development of differentiation syndrome (DS), which can be fatal. We examined the role of HMGB1 (high-mobility group

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