C2866
Anti-Cannabinoid Receptor 1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
availability
not available in Japan
technique(s)
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 8-11 μg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
target post-translational modification
unmodified
Gene Information
human ... CNR1(1268)
mouse ... Cnr1(12801)
rat ... Cnr1(25248)
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General description
Cannabinoid receptor type 1 (CNR1) is a G protein-coupled cannabinoid receptor found in central and peripheral nervous system. CNR1 belongs to rhodopsin-like G protein-coupled receptor superfamily.
Immunogen
synthetic peptide corresponding to the third cytoplasmic loop of human cannabinoid receptor 1, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
Application
Anti-Cannabinoid Receptor 1 antibody produced in rabbit is suitable for immunocytochemistry and immunohistochemistry using formalin-fixed and paraffin-embedded sections at a concentration of 8-11μg/mL.
Biochem/physiol Actions
CNR1 has implications in several disease states, including drug addiction, anxiety, depression, obesity, and chronic pain. Different classes of CNR1 agonists are involved in signaling pathways through the activation of specific subtypes of G proteins. It may play a key role for the treatment of negative affective state produced by alcohol withdrawal and abstinence which is critical for the maintenance of alcohol addiction. CNR1 genes also play some roles in common polymorphism (rs1049353) with potential implications in weight loss.
Physical form
Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Xue Shen et al.
BioMed research international, 2019, 5468954-5468954 (2019-02-26)
Adenomyosis is a common gynecologic benign disease that may have a life-long negative impact on women. Previous studies have indicated that the endocannabinoid system may participate in the progress of endometriosis. Our research aims to analyze the expression patterns of
Daniel Antonio de Luis et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 62(2), 324-327 (2013-12-11)
A polymorphism (1359 G/A) of the cannabinoid receptor 1 (CNR1) gene was reported as a common polymorphism (rs1049353) with potential implications in weight loss. We decide to investigate the role of this polymorphism on metabolic changes and weight loss secondary
Joong-Youn Shim et al.
The Journal of biological chemistry, 288(45), 32449-32465 (2013-10-05)
The cannabinoid (CB1) receptor is a member of the rhodopsin-like G protein-coupled receptor superfamily. The human CB1 receptor, which is among the most expressed receptors in the brain, has been implicated in several disease states, including drug addiction, anxiety, depression
Jenny Ceccarini et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(8), 2822-2831 (2014-02-21)
Involvement of the type 1 cannabinoid receptor (CB1R) in the effects of alcohol on the brain is supported by animal experiments, but how in vivo CB1R levels are altered in alcoholic patients is still unclear. To assess the short-time effects
Özge Boyacıoğlu et al.
Cell death & disease, 12(1), 56-56 (2021-01-13)
Therapeutic agents used for non-small cell lung cancer (NSCLC) have limited curative efficacy and may trigger serious adverse effects. Cannabinoid ligands exert antiproliferative effect and induce apoptosis on numerous epithelial cancers. We confirmed that CB1 receptor (CB1R) is expressed in
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