C25120
CM Sephadex® C-25
Synonym(s):
CM Sephadex®, Carboxymethyl Sephadex®
form
powder
technique(s)
activity assay: suitable
matrix
cross-linked dextran
bead size
40-125 μm (dry)
pore size
~30,000 Da exclusion limit
operating pH
6-10
pH
2—12
capacity
4.0-5.0 meq/g ion exchange capacity
compatibility
mode of use weak cation exchange chromatography
Quality Level
Related Categories
General description
C25120-100G′s updated product number is GE17-0210-01
Application
Sephadex® C-25 is used in ion exchange chromatography, cation exchange media, protein chromatography, separation media and resins. Sephadex® C-25 has been used to study wasp envenomation and to demonstrate that snake protease inhibitors and neurotoxic homologs originated from a common ancestor.
Legal Information
Sephadex is a registered trademark of Cytiva
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Junyou Han et al.
Toxicon : official journal of the International Society on Toxinology, 51(5), 914-922 (2008-03-01)
Wasp is an important venomous animal that can induce human fatalities. Coagulopathy is a clinical symptom after massive wasp stings, but the reason leading to the envenomation manifestation is still not known. In this paper, a toxin protein is purified
Cleonice C Santos et al.
Toxicology in vitro : an international journal published in association with BIBRA, 42, 54-60 (2017-04-11)
Aminochrome has been suggested as a more physiological preclinical model capable of inducing five of the six mechanisms of Parkinson's Disease (PD). Until now, there is no evidence that aminochrome induces glial activation related to neuroinflammation, an important mechanism involved
Jia Lu et al.
Peptides, 29(3), 369-374 (2008-01-01)
By Sephadex G-50 gel filtration, cation-exchange CM-Sephadex C-25 chromatography and reversed phase high-performance liquid chromatography (HPLC), a novel serine protease inhibitor named bungaruskunin was purified and characterized from venom of Bungarus fasciatus. Its cDNA was also cloned from the cDNA
J W Adelson et al.
The Journal of biological chemistry, 261(23), 10569-10575 (1986-08-15)
Chymodenin, a hormone-like duodenal peptide which rapidly alters the proportions of secreted pancreatic digestive enzymes to a mixture relatively richer in chymotrypsinogen than that found in basal secretion, has been purified to homogeneity. The starting material was an acidic methanol-soluble
Susan M Paskewitz et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 150(4), 403-408 (2008-06-07)
The production of melanin is a complex biochemical process in which several enzymes may play a role. Although phenoloxidase and serine proteases are clearly key components, the activity of other enzymes, including dopa decarboxylase and dopachrome conversion enzyme may also
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