C1897
Catechol-O-methyl Transferase from porcine liver
lyophilized powder, ≥150 units/mg protein
Synonym(s):
COMT, Pyrocatechol-O-methyl Transferase, S-Adenosyl-L-methionine:catechol O-methyltransferase
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About This Item
CAS Number:
UNSPSC Code:
12352200
EC Number:
232-727-6
MDL number:
Product Name
Catechol-O-methyl Transferase from porcine liver, lyophilized powder, ≥150 units/mg protein
form
lyophilized powder
specific activity
≥150 units/mg protein
purified by
chromatography
composition
Protein, 30-60% biuret
storage temp.
−20°C
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Biochem/physiol Actions
Major degradative enzyme for catecholamine neurotransmitters; methylates the o-hydroxyl group
Other Notes
One unit will produce 1.0 nanomole of total O-methylated products from 3,4 dihydroxyacetophenone per hour at pH 7.6 at 37 °C.
Previous radioactive assay unit definition: One unit will catalyze the methylation of 1.0 nanomole of protocatechuic acid per hr at pH 7.9 at 37°C using S-adenosyl-L-[methyl-14C]methionine as the methyl donor. (~6 radioactive units equal one new unit).
Previous radioactive assay unit definition: One unit will catalyze the methylation of 1.0 nanomole of protocatechuic acid per hr at pH 7.9 at 37°C using S-adenosyl-L-[methyl-14C]methionine as the methyl donor. (~6 radioactive units equal one new unit).
Physical form
Lyophilized powder containing phosphate buffer and dithiothreitol
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Luis Almeida et al.
Clinical pharmacokinetics, 52(2), 139-151 (2012-12-19)
Opicapone is a novel catechol-O-methyltransferase (COMT) inhibitor. The purpose of this study was to evaluate the tolerability, pharmacokinetics (including the effect of food) and pharmacodynamics (effect on COMT activity) following single oral doses of opicapone in young healthy male volunteers.
Excessive daytime sleepiness and its risk factors in incident Parkinson's disease.
David P Breen et al.
Journal of neurology, neurosurgery, and psychiatry, 84(2), 233-234 (2012-11-28)
Nidhi Jatana et al.
Journal of molecular graphics & modelling, 39, 145-164 (2013-01-03)
Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation. COMT has been a subject of study for its implications in numerous neurological disorders like Parkinson's disease (PD), schizophrenia, and depression. The
M C Wardle et al.
Genes, brain, and behavior, 12(1), 13-20 (2012-12-13)
In a widely cited study, Mattay et al. reported that amphetamine (0.25 mg/kg oral, or 17 mg for a 68 kg individual) impaired behavioral and brain indices of executive functioning, measured using the Wisconsin Card Sorting Task (WCST) and N-Back
D B Spronk et al.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 124(5), 909-915 (2012-12-25)
The amplitude and latency of the P300 may be associated by variations in dopaminergic genes. The current study was conducted to determine whether functional variants of the catechol-O-methyltransferase (COMT) and dopamine beta-hydroxylase (DBH) gene were associated with P300 amplitude and
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