C188
6-Hydroxychlorzoxazone
solid
Synonym(s):
5-Chloro-6-hydroxy-2(3H)-benzoxazolone, 5-Chloro-6-hydroxybenzoxazone
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About This Item
Empirical Formula (Hill Notation):
C7H4ClNO3
CAS Number:
Molecular Weight:
185.56
UNSPSC Code:
12161501
PubChem Substance ID:
MDL number:
InChI
1S/C7H4ClNO3/c8-3-1-4-6(2-5(3)10)12-7(11)9-4/h1-2,10H,(H,9,11)
SMILES string
Oc1cc2OC(=O)Nc2cc1Cl
InChI key
AGLXDWOTVQZHIQ-UHFFFAOYSA-N
form
solid
solubility
H2O: insoluble, ethanol: moderately soluble
Application
CYP2E1 & 1A2 metabolite of chlorzoxazone.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Eva González-Jasso et al.
Toxicology letters, 144(1), 55-67 (2003-08-16)
The inducibility of CYP2E1 was investigated in liver and peripheral lymphocytes of rats treated with benzene (0-10 mmol/kg body weight (bw), daily for 3 days, i.p., or 0 and 5 mmol/kg bw, daily for 14 days, i.p.) or toluene (0
Hye W Baek et al.
Journal of pharmaceutical sciences, 95(11), 2452-2462 (2006-08-04)
Pharmacokinetic parameters of chlorzoxazone (CZX) and its main metabolite, 6-hydroxychlorzoxazone (OH-CZX), were compared after intravenous (20 mg/kg) and oral (50 mg/kg) administration of CZX in rat model of diabetes induced by alloxan (DMIA) or streptozotocin (DMIS), and their respective control
Young Jin Moon et al.
Drug metabolism and disposition: the biological fate of chemicals, 31(6), 776-784 (2003-05-21)
The purpose of this study is to report the changes of CYP2E1, CYP1A2, CYP2B1/2, CYP2C11, CYP3A23, and CYP3A2 expression and pharmacokinetics and tissue distribution of chlorzoxazone (CZX) and 6-hydroxychlorzoxazone (OH-CZX) in rats with acute renal failure induced by uranyl nitrate
M Reza Anari et al.
Analytical chemistry, 75(3), 469-478 (2003-02-15)
The application of liquid chromatography tandem mass spectrometry for simultaneous analysis of major human cytochrome P450 activities via a single atmospheric pressure ionization (API) LC/MS/MS method has been hampered by the preferred detection of 6-hydroxychlorzoxazone (HCZ), the metabolite of the
Anna M Lee et al.
European journal of pharmacology, 552(1-3), 151-158 (2006-10-20)
Cytochrome P450 2E1 (CYP2E1) is expressed in the brain and liver, and can metabolize clinical drugs and activate toxins. The effect of phenobarbital on hepatic and brain CYP2E1 is unclear. We investigated the effect of chronic phenobarbital treatment on in
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