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Merck
CN

C160

CGP-42112A

synthetic, ≥95%, Angiotensin II receptor antagonist, solid

Synonym(s):

Nα-Nicotinoyl-Tyr-(Nα-Cbz-Arg)-Lys-His-Pro-Ile

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About This Item

Empirical Formula (Hill Notation):
C52H69N13O11
CAS Number:
127060-75-7
Molecular Weight:
1052.18
NACRES:
NA.77
PubChem Substance ID:
24892424
UNSPSC Code:
12352200
MDL number:
MFCD00133611
Beilstein/REAXYS Number:
8184948

Key Documents

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Product Name

CGP-42112A, ≥95%, synthetic, solid

InChI key

UXGNARZDONUMMK-LRMQDCNJSA-N

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)c5cccnc5)C(O)=O

InChI

1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1

biological source

synthetic

assay

≥95%

form

solid

color

white

storage temp.

−20°C

Quality Level

200

Gene Information

human ... AGTR2(186)
rat ... AGTR2(11609)

Related Categories

Application

CGP-42112A has been used:
  • in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
  • to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
  • as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

Biochem/physiol Actions

CGP-42112A is a potent angiotensin II type 2 receptor (AT2R) agonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000511932
0000511932
0000484342
0000484342
0000492066

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Anu Vaajanen et al.
Investigative ophthalmology & visual science, 49(6), 2557-2562 (2008-01-29)
In the present study the effects of exogenous angiotensin II and its breakdown metabolite angiotensin (1-7) on the intraocular pressure (IOP) and on aqueous humor dynamics in normotensive rabbit eye were evaluated. Male New Zealand White rabbits with normal IOP
C Sumners et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(17), 7567-7571 (1991-09-01)
Both neurons and astrocytes contain specific receptors for angiotensin II (AII). We used selective ligands for the AT1 and AT2 types of AII receptors to investigate the expression of functional receptor subtypes in astrocyte cultures and neuron cultures from 1-day-old
Nancy J Hong et al.
Hypertension (Dallas, Tex. : 1979), 60(3), 765-769 (2012-07-11)
NO reduces NaCl absorption by thick ascending limbs (TALs) by inhibiting the Na/K/2Cl cotransporter (NKCC2). We have shown that NO-induced inhibition of Na transport is reduced in Dahl salt-sensitive rat (SS) TALs. Angiotensin II increases NO production in TALs via
Claudia A McCarthy et al.
Hypertension (Dallas, Tex. : 1979), 60(6), 1531-1537 (2012-10-24)
We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor (AT(2)R) agonist is neuroprotective against a subsequent stroke independent of any changes in blood pressure. Therefore, in the current study, we have examined the potential neuroprotective effect
Liping Zhu et al.
American journal of physiology. Heart and circulatory physiology, 302(12), H2553-H2559 (2012-04-24)
ANG II type 2 receptors (AT(2)R) elicit cardioprotective effects in part by stimulating the release of kinins; however, the mechanism(s) responsible have not been fully explored. We demonstrated previously that overexpression of AT(2)R increased expression of prolylcarboxypeptidase (PRCP; a plasma
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