C1497
Anti-CCL17/TARC antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-A-152E5.3, Anti-ABCD-2, Anti-SCYA17, Anti-TARC
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL
neutralization: suitable
western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CCL17(6361)
General description
Chemokine (C-C motif) ligand 17 (CCL17) belonging to the CC chemokine family. It is also known as thymus and activation regulated chemokine (TARC), ABCD-2, SCYA17, A-152E5.3. It is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells.
Immunogen
purified, E. coli-derived, recombinant human CCL-17.
Application
Anti-CCL17/TARC antibody produced in goat is suitable for the following applications:
- Immunohistochemistry using formalin-fixed and paraffin-embedded sections at a concentration of 5-15μg/mL.
- Neutralization
- Western blotting at a concentration of 0.1-0.2μg/mL
Biochem/physiol Actions
Thymus and activation regulated chemokine (TARC) may play an important role in T cell development as well as in trafficking and activation of mature T cells. It functions as a selective chemo-attractant for T cells that express a class of receptors binding TARC with high affinity and specificity. TARC acts as a functional ligand for CCR4, and CCR4 that are specific receptor for TARC selectively expressed on T cells. In Hodgkin lymphoma (HL) disease it is highly expressed and is a possible biomarker in HL patients. TARC expression is resistant to corticosteroid and is suppressed by PI3K enzyme inhibitors.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
13 - Non Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Maike Sauer et al.
American journal of hematology, 88(2), 113-115 (2012-12-12)
Hodgkin lymphoma (HL) has become one of the best curable cancers. However, better biomarkers are needed for outcome prediction that would allow protecting patients from over- or under-dosing of treatment. Thymus and activation-regulated chemokine/CCL17 (TARC) is highly and specifically elevated
Karl J Staples et al.
The Journal of allergy and clinical immunology, 130(6), 1404-1412 (2012-09-18)
Studies with monocyte-derived macrophages (MDMs) and animal models have suggested a role for alternatively activated (M2) macrophages in asthmatic inflammation, but in vivo evidence for this phenotype in human asthma is lacking. To characterize the phenotype of lung macrophages from asthmatic
T Imai et al.
The Journal of biological chemistry, 271(35), 21514-21521 (1996-08-30)
Precursors of most secreted and cell surface molecules carry signal sequences at their amino termini. Here we describe an efficient signal sequence trap method and isolation of a novel CC chemokine. An expression library was constructed by inserting 5' portion-enriched
T Imai et al.
The Journal of biological chemistry, 272(23), 15036-15042 (1997-06-06)
Thymus and activation-regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells. TARC functions as a selective chemoattractant for T cells that express a class of receptors
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