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C127

CNQX

Name: CNQX
Brand: SIGMA

≥98% (HPLC), AMPA/kainate glutamate receptor antagonist, solid

Synonym(s):

6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065

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About This Item

Empirical Formula (Hill Notation):

C₉H₄N₄O₄

CAS Number:

115066-14-3

Molecular Weight:

232.15

UNSPSC Code:

12352200

PubChem Substance ID:

24892392

NACRES:

NA.77

MDL number:

MFCD00069232

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

protect from light

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Properties

Product Name

CNQX, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

yellow

solubility

DMSO: >10 mg/mL, H₂O: insoluble

SMILES string

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N

InChI

1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)

InChI key

RPXVIAFEQBNEAX-UHFFFAOYSA-N

Gene Information

rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409)

Description

Application

CNQX has been used:

as an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate blocker to study its effects on cytoneme formation in pluripotent embryonic stem cells (pESCs)
glutamate blocker to reduce the synaptic input during current-clamp recordings in central antennal lobe neurons
as a non-N-methyl-D-aspartate (NMDA) receptor blocker to study its effects on the heart rate in rats

Biochem/physiol Actions

Potent, competitive AMPA/kainate glutamate receptor antagonist.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3.

Haiyan Li et al.

Frontiers in cellular neuroscience, 11, 324-324 (2017-11-11)

Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that

Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats.

Binbin Yan et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 296(2), R299-R308 (2008-11-21)

Chronic intermittent hypoxia (CIH), as occurs in sleep apnea, impairs baroreflex-mediated reductions in heart rate (HR) and enhances HR responses to electrical stimulation of vagal efferent. We tested the hypotheses that HR responses to activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and

The paracetamol metabolite N-acetylp-benzoquinone imine reduces excitability in first- and second-order neurons of the pain pathway through actions on KV7 channels.

Sutirtha Ray et al.

Pain, 160(4), 954-964 (2019-01-03)

Paracetamol (acetaminophen, APAP) is one of the most frequently used analgesic agents worldwide. It is generally preferred over nonsteroidal anti-inflammatory drugs because it does not cause typical adverse effects resulting from the inhibition of cyclooxygenases, such as gastric ulcers. Nevertheless

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Global Trade Item Number

SKU	GTIN
C127-50MG	04061833467251
C127-25MG	04061833467244
C127-5MG	04061832089621