All Photos(1)
Synonym(s):
Cholesterol, water soluble from sheep, Cholesteryl-polyethylene glycol 600 sebacate, Polyethylene glycol 600 mono(cholesteryl) ether sebacate, Polyoxyethyl-cholesteryl sebacate
Recommended Products
form
solid
Quality Level
extent of labeling
≥20% cholesterol
color
light yellow
solubility
H2O: 60 mg/mL
shipped in
dry ice
storage temp.
−20°C
General description
Cholesterol is one of the important constituent of all membranes. It is made up of a hydrophobic, planar, a polar hydroxyl group, fused-ring nucleus and a short hydrocarbon tail.
Application
Cholesterol-PEG 600 has been used to evaluate its ability to induce apoptosis in vascular smooth muscle cells. It has also been used to restore cholesterol following depletion by methyl β-cyclodextrin.
Biochem/physiol Actions
Cholesterol acts as an antecedent of steroid hormones. It plays a key role in fetal growth and in brain development.
Physical form
semisolid to solid
Preparation Note
Prepared by method of Proksch, G.J., and Bonderman, D.P., Clin. Chem., 24, 1924 (1978).
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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The Lipids of Biological Membranes
The Membranes of Cells null
M Absi et al.
British journal of pharmacology, 151(3), 332-340 (2007-04-24)
The small and intermediate conductance, Ca2+-sensitive K+ channels (SK(Ca) and IK(Ca), respectively) which are pivotal in the EDHF pathway may be differentially activated. The importance of caveolae in the functioning of IK(Ca) and SK(Ca) channels was investigated. The effect of
Linda Shaw et al.
Cardiovascular research, 69(4), 825-835 (2006-02-09)
A close association of caveolae and sarcoplasmic reticulum (SR) has been suggested to be important for contractile activation of smooth muscle. Here, we investigate the presence of such arrangements in pressurised resistance arteries and examine the influence of two agents
Apoptosis of vascular smooth muscle cells induced by cholesterol and its oxides in vitro and in vivo
Yin J, et al.
Atherosclerosis, 148(2), 365-374 (2000)
Disruption of cholesterol homeostasis in developmental neurotoxicity
Reproductive and Developmental Toxicology null
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