C112000
DMT-dC(tac) Phosphoramidite
Synonym(s):
DMT-dC(tac) amidite, N-[2-[4-(1,1-dimethylethyl)phenoxy]acetyl]-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxycytidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
About This Item
type
for DNA synthesis
Quality Level
product line
Proligo Reagents
Assay
≥98% (31P-NMR)
≥98.0% (reversed phase HPLC)
form
powder
technique(s)
oligo synthesis: suitable
λ
conforms (UV/VIS Identity)
nucleoside profile
base: deoxycytidine
base protecting group: TAC
2' protecting group: none
5' protecting group: DMT
deprotection: fast
storage temp.
-10 to -25°C
SMILES string
CC(C)N(C(C)C)P(OCCC#N)O[C@H]1C[C@@H](O[C@@H]1COC(c2ccccc2)(c3ccccc3)c4ccccc4)N5C=CC(NC(=O)COc6ccc(cc6)C(C)(C)C)=NC5=O
InChI
1S/C49H58N5O7P/c1-35(2)54(36(3)4)62(59-31-17-29-50)61-42-32-46(53-30-28-44(52-47(53)56)51-45(55)34-57-41-26-24-37(25-27-41)48(5,6)7)60-43(42)33-58-49(38-18-11-8-12-19-38,39-20-13-9-14-21-39)40-22-15-10-16-23-40/h8-16,18-28,30,35-36,42-43,46H,17,31-34H2,1-7H3,(H,51,52,55,56)/t42-,43+,46+,62?/m0/s1
InChI key
NHKNJNORWFDRBB-ROEGVEHFSA-N
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General description
Other Notes
- The deprotection of oligonucleotide synthesis products with the AMAreagent is ultra-fast: complete deprotection requires 10 minutes at 65 °C
- Side reactions at C-monomers through transamination are eliminated
- Not compatible with some base-labile modified nucleosides
- dC(tac)-phosphoramidite can directly substitute for dC(bz)-phosphoramidite
- No change is required in the reagents commonly used for DNA synthesis.Acetonitrile is used to dissolve phosphoramidite. The standard aceticanhydride capping reagent can be employed.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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