C111000
DMT-dC(bz) Phosphoramidite
Synonym(s):
Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite], DMT-dC(bz) amidite, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxycytidine, 3′-[2-cyanoethyl N,N-?bis(1-methylethyl)phosphoramidite], N4-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
About This Item
biological source
non-animal source (no BSE/TSE risk)
Quality Level
type
for DNA synthesis
product line
Proligo Reagents
Assay
≥99% (31P-NMR)
≥99.0% (reversed phase HPLC)
form
powder or granules
technique(s)
oligo synthesis: suitable
impurities
≤0.3 wt. % water content (Karl Fischer)
color
white to off-white
λ
conforms (UV/VIS Identity)
nucleoside profile
base: deoxycytidine
base protecting group: benzoyl
2' protecting group: none
5' protecting group: DMT
deprotection: standard
storage temp.
2-8°C
SMILES string
COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(=O)c4ccccc4)=NC3=O)(c5ccccc5)c6ccc(OC)cc6
InChI
1S/C46H52N5O8P/c1-32(2)51(33(3)4)60(57-29-13-27-47)59-40-30-43(50-28-26-42(49-45(50)53)48-44(52)34-14-9-7-10-15-34)58-41(40)31-56-46(35-16-11-8-12-17-35,36-18-22-38(54-5)23-19-36)37-20-24-39(55-6)25-21-37/h7-12,14-26,28,32-33,40-41,43H,13,29-31H2,1-6H3,(H,48,49,52,53)/t40-,41+,43+,60?/m0/s1
InChI key
PGTNFMKLGRFZDX-SALLYJDFSA-N
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General description
- Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib))
- Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution, for standard base-protected oligonucleotides
- The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides
Certificates of Analysis (COA)
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