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Merck
CN

C1011

N-Cyclohexyl-N′-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate

≥97% (CHN)

Synonym(s):

N-Cyclohexyl-N′-(β-[N-methylmorpholino]ethyl)carbodiimide p-toluenesulfonate, CMC, CME-CDI

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About This Item

Empirical Formula (Hill Notation):
C14H26N3O · C7H7O3S
CAS Number:
2491-17-0
Molecular Weight:
423.57
EC Number:
219-650-3
UNSPSC Code:
12352200
PubChem Substance ID:
24892296
Beilstein/REAXYS Number:
3872192
MDL number:
MFCD00011979

Key Documents

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InChI key

GBCAVSYHPPARHX-UHFFFAOYSA-M

InChI

1S/C14H26N3O.C7H8O3S/c1-17(9-11-18-12-10-17)8-7-15-13-16-14-5-3-2-4-6-14;1-6-2-4-7(5-3-6)11(8,9)10/h14H,2-12H2,1H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

SMILES string

Cc1ccc(cc1)S([O-])(=O)=O.C[N+]2(CCOCC2)CCN=C=NC3CCCCC3

assay

≥97% (CHN)

form

powder

technique(s)

ligand binding assay: suitable

color

white

mp

109-111 °C

application(s)

peptide synthesis

storage temp.

−20°C

Application

Water-soluble condensing reagent for peptide synthesis, reagent used for coupling ligands to carriers in affinity chromatography.

Biochem/physiol Actions

N-Cyclohexyl-N′-(2-morpholinoethyl)carbodiimide (CMCT) selectively modifies/derivitizes all pseudouridine, thiouridine and 2-methylthio-6-isopentenyladenosine nucleosides for detection by methods such as matrix-assisted laser desorption/ionization mass spectrometry. CMCT, a water-soluble condensing reagent for peptide synthesis, is used as a reagent for coupling ligands to carriers in affinity chromatography.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
STBF6345V
S63727V
STBC9029V
STBC6176V
STBC4268V

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Mei-Hui Wang et al.
Journal of hepatology, 63(2), 370-377 (2015-03-24)
The asialoglycoprotein receptor on hepatocyte membranes recognizes the galactose residues of glycoproteins. We investigated the specificity, accuracy and threshold value of asialoglycoprotein receptor imaging for estimating liver reserve via scintigraphy using (111)In-hexavalent lactoside in mouse models. (111)In-hexavalent lactoside scintigraphy for
M S Sloma et al.
Biochimica et biophysica acta, 1521(1-3), 30-38 (2001-11-03)
We have investigated possible interaction sites for mRNA, tRNA, translation factors and the nascent peptide on 5S, 5.8S and 28S rRNA in in vivo assembled translational active mouse ribosomes by comparing the chemical footprinting patterns derived from native polysomes, salt-washed
Yongjun Wei et al.
PloS one, 10(6), e0129921-e0129921 (2015-06-13)
Diverse cellulolytic bacteria are essential for maintaining high lignocellulose degradation ability in biogas digesters. However, little was known about functional genes and gene clusters of dominant cellulolytic bacteria in biogas digesters. This is the foundation to understand lignocellulose degradation mechanisms
Renata A Castro et al.
SpringerPlus, 3, 382-382 (2014-08-12)
The mangrove ecosystem is a coastal tropical biome located in the transition zone between land and sea that is characterized by periodic flooding, which confers unique and specific environmental conditions on this biome. In these ecosystems, the vegetation is dominated
Katherine A Kellersberger et al.
Analytical chemistry, 76(9), 2438-2445 (2004-05-01)
A top-down approach based on sustained off-resonance irradiation collision-induced dissociation (SORI-CID) has been implemented on an electrospray ionization (ESI) Fourier transform mass spectrometer (FTMS) to characterize nucleic acid substrates modified by structural probes. Solvent accessibility reagents, such as dimethyl sulfate
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