Skip to Content
Merck
CN
All Photos(2)

Key Documents

View All Documentation

C0609

Sigma-Aldrich

Carnosic acid from Rosmarinus officinalis

≥91%, powder

Synonym(s):

(4AR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C20H28O4
CAS Number:
3650-09-7
Molecular Weight:
332.43
MDL number:
MFCD02259459
UNSPSC Code:
12352106
PubChem Substance ID:
329774804
NACRES:
NA.25

Quality Level

200

Assay

≥91%

form

powder

color

faintly yellow to dark yellow

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC(C)c1cc2CC[C@H]3C(C)(C)CCC[C@]3(C(O)=O)c2c(O)c1O

InChI

1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14-,20+/m0/s1

InChI key

QRYRORQUOLYVBU-VBKZILBWSA-N

Application

Carnosic acid from Rosmarinus officinalis is used to study its mechanisms as an antioxidant that protects lipids from peroxidation and proteins from carbonylation. Carnosic acid is used to assess its neuroprotective activies including its ability to modulate the neurotoxic effects of 6-hydroxydopamine (6-OHDA). Carnosic acid may also be used to study it anticancer potential.
Phenolic compound that is naturally occurring with antioxidant properties. Inhibits lipid peroxidation which is caused by NADH or NADPH oxidation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000365448
0000355138
0000336454
0000327206
0000309408

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How does one prepare a stock solution of product C0609, Carnosic acid from Rosmarinus officinalis?

    A stock solution of C0609, Carnosic acid from Rosmarinus officinalis acid, can be prepared at 1 mg/ml in DMSO.

  6. At what final concentration can product C0609, Carnosic acid from Rosmarinus officinalis, be used?

    Product C0609, Carnosic acid from Rosmarinus officinalis, can be used at a final concentration of 0.1-1.0 μg/ml (equivalent to 0.3-3.0 micromoles per liter). This information comes from a study of the photoprotective potential of dietary antioxidants including carnosic acid in human dermal fibroblasts exposed to ultraviolet-A (UVA) light.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Tayebeh Rezaie et al.
Investigative ophthalmology & visual science, 53(12), 7847-7854 (2012-10-20)
The herb rosemary has been reported to have antioxidant and anti-inflammatory activity. We have previously shown that carnosic acid (CA), present in rosemary extract, crosses the blood-brain barrier to exert neuroprotective effects by upregulating endogenous antioxidant enzymes via the Nrf2
Linda Saxe Einbond et al.
Fitoterapia, 83(7), 1160-1168 (2012-07-26)
Studies indicate that extracts and purified components, including carnosic acid, from the herb rosemary display significant growth inhibitory activity on a variety of cancers. This paper examines the ability of rosemary/carnosic acid to inhibit the growth of human breast cancer
Mariano Walter Pertino et al.
Journal of natural products, 73(4), 639-643 (2010-04-03)
Carnosic acid (1) has been shown to possess gastroprotective activity in vitro and in vivo. However, little is known of the gastroprotective effect or cytotoxicity of carnosic acid gamma-lactone (3). To determine structure-activity relationships, a series of 17 esters of
Riham Salah El Dine et al.
Journal of natural products, 72(11), 2019-2023 (2009-10-10)
A new farnesyl hydroquinone, ganomycin I (1), was isolated along with ganomycin B (2) from the chloroform extract of the fruiting bodies of the Vietnamese mushroom Ganoderma colossum. These compounds inhibited HIV-1 protease with IC50 values of 7.5 and 1.0
A I Kuzmenko et al.
Journal of photochemistry and photobiology. B, Biology, 48(1), 63-67 (1999-04-17)
Lipid free-radical oxidation has been studied in vivo in the mitochondrial fractions of the liver of rats fed RoseOx (carnosic acid nutritional supplement) by measuring chemiluminescence. The kinetics of the lipid chemiluminescence in rats fed RoseOx are significantly different from
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service