C0483
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin
≥95%, solid
Synonym(s):
Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC
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About This Item
Empirical Formula (Hill Notation):
C35H44N4O9
Molecular Weight:
664.75
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Quality Level
assay
≥95%
form
solid
solubility
DMSO: soluble
storage temp.
−20°C
SMILES string
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI
1S/C35H44N4O9/c1-20(2)15-27(38-34(45)28(16-21(3)4)39-35(46)47-19-23-9-7-6-8-10-23)33(44)37-26(13-14-30(40)41)32(43)36-24-11-12-25-22(5)17-31(42)48-29(25)18-24/h6-12,17-18,20-21,26-28H,13-16,19H2,1-5H3,(H,36,43)(H,37,44)(H,38,45)(H,39,46)(H,40,41)/t26-,27-,28-/m0/s1
InChI key
FOYHOBVZPWIGJM-KCHLEUMXSA-N
General description
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity.
Application
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples.
Biochem/physiol Actions
Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.
Fluorogenic substrate to measure peptidylglutamyl-peptide hydrolyzing activity of 20S proteasome.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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P Berthon et al.
Pflugers Archiv : European journal of physiology, 454(4), 625-633 (2007-03-06)
In the present study, we determined the impact of 5 and 10 days of muscle deconditioning induced by hindlimb suspension (HS) on the ubiquitin-proteasome system of protein degradation and caspase enzyme activities in rat soleus muscles. A second goal was
Caterina Branca et al.
Neurobiology of aging, 35(12), 2726-2735 (2014-07-19)
Currently, there are no available approaches to cure or slow down the progression of Alzheimer's disease (AD), which is characterized by the accumulation of extracellular amyloid-β (Aβ) deposits and intraneuronal tangles that comprised hyperphosphorylated tau. The β2 adrenergic receptors (β2ARs)
O I Savchuk et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 61(5), 11-20 (2016-02-06)
Functional as well as structural reorganization of brain tissues takes place in the surrounding and remotes brain areas after focal ischemic lesions. In particular, reactive or regenerative processes have been described to occur in the infarction areas and the contralateral
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C0483-5MG | 04061833260630 |