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Merck
CN

C0399

Cromolyn sodium salt

≥95%, Mast cell stabilizer, powder

Synonym(s):

Cromoglycate, Cromoglycic acid

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About This Item

Linear Formula:
C23H14O11Na2
CAS Number:
15826-37-6
Molecular Weight:
512.33
NACRES:
NA.77
PubChem Substance ID:
24892251
UNSPSC Code:
12352200
EC Number:
239-926-7
MDL number:
MFCD00057744

Key Documents

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Product Name

Cromolyn sodium salt, ≥95%

InChI key

UXMUBZWVLQEMRB-UHFFFAOYSA-N

InChI

1S/C23H16O11.Na.H/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;

SMILES string

[Na].OC(COc1cccc2OC(=CC(=O)c12)C(O)=O)COc3cccc4OC(=CC(=O)c34)C(O)=O

assay

≥95%

form

powder

originator

Sanofi Aventis

Quality Level

200

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Application

Cromolyn sodium salt has been used to block mast cell activation and to inhibit histamine secretion from rodent peritoneal mast cells. It has also been used to stabilize mast cells.

Biochem/physiol Actions

Cromolyn blocks the release of histamine and other pro-inflammatory mediators from mast cells.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Cromolyn sodium is a mast stabilizer, which is used to treat allergies. It is a bischromone and functions as a non-steroidal anti-inflammatory drug. It inhibits the release of histamines from mast cells.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN5428
BCCM9688
BCCK4119
BCBR3851V
BCBL3456V

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Zhi Liu et al.
Journal of autoimmunity, 31(4), 331-338 (2008-10-17)
Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome. Numerous inflammatory cells infiltrate the upper dermis in BP. IgG autoantibodies in BP fix
Mechanistic understanding of oral drug absorption enhancement of cromolyn sodium by an amino acid derivative
Alani AWG and Robinson JR
Pharmaceutical Research, 25(1), 48-54 (2008)
Reginald Gorczynski et al.
Transplantation, 97(1), 39-46 (2013-10-22)
Rejection is associated with early degranulation (≥80%) of graft-infiltrating CD200R1 receptor-positive mast cells (MCs). Survival is increased, and MC degranulation is decreased, in CD200 mice but not in CD200R1KO mice. CD200 engagement of CD200R2 (not present on MCs) alters dendritic
Rhinitis, An Issue of Immunology and Allergy Clinics - E-Book (2011)
Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents
Esquerre N, et al.
Cellular and molecular gastroenterology and hepatology, 7(1), 185-196 (2019)
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