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Merck
CN

C0330

Ciprofibrate

Synonym(s):

2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

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About This Item

Empirical Formula (Hill Notation):
C13H14Cl2O3
CAS Number:
52214-84-3
Molecular Weight:
289.15
NACRES:
NA.77
PubChem Substance ID:
24278288
UNSPSC Code:
41116107
EC Number:
257-744-6
MDL number:
MFCD00467135

Key Documents

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InChI key

KPSRODZRAIWAKH-UHFFFAOYSA-N

InChI

1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)

SMILES string

CC(C)(Oc1ccc(cc1)C2CC2(Cl)Cl)C(O)=O

form

powder

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... PPARA(5465)

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Related Categories

Biochem/physiol Actions

Peroxisome proliferator-activated receptor α (PPARα) agonist

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H350

Hazard Classifications

Carc. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
019M4057V
13181125
098M4064V
13160319
068M4118V

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Chae Hwa Kwon et al.
Toxicology, 244(1), 13-24 (2007-12-18)
Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists have been reported to induce apoptosis in a variety of cell types including renal proximal epithelial cells. However, the underlying mechanism of cell death induced by PPARgamma agonists has not been clearly defined in
Karen G Calfee-Mason et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46(6), 2062-2073 (2008-03-14)
Peroxisome proliferators (PPs) are a diverse class of chemicals, which cause a dramatic increase in the size and number of hepatic peroxisomes in rodents and eventually lead to the development of hepatic tumors. Nuclear factor-kappaB (NF-kappaB) is a transcription factor
Wei Xie et al.
Archives of toxicology, 83(10), 909-924 (2009-06-23)
Perfluorooctanesulfonamides, such as N-ethyl perfluorooctanesulfonamidoethanol (N-EtFOSE), are large scale industrial chemicals but their disposition and toxicity are poorly understood despite significant human exposure. The hypothesis that subacute exposure to N-EtFOSE, a weak peroxisome proliferator, causes a redox imbalance in vivo
P Passilly et al.
Biochemical pharmacology, 58(6), 1001-1008 (1999-10-06)
The basic mechanism(s) by which peroxisome proliferators activate peroxisome proliferator-activated receptors (PPARs) is (are) not yet fully understood. Given the diversity of peroxisome proliferators, several hypotheses of activation have been proposed. Among them is the notion that peroxisome proliferators could
Zakaria El Kebbaj et al.
Endocrinology, 150(3), 1192-1201 (2008-10-25)
Seasonal obesity and fasting-associated hibernation are the two major metabolic events governing hepatic lipid metabolism in hibernating mammals. In this process, however, the role of the nuclear receptor known as peroxisome proliferator-activated receptor (PPAR)-alpha has not been elucidated yet. Here
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