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BX-0900-30

Human Microglia

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Human iPSC line, Fully differentiated, Healthy Male Control (no known neurological disorders), Cryopreserved

Synonym(s):

Brain macrophages

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biological source

human (iPSC line)

form

frozen liquid

packaging

vial of 1 (contains ≥1 million cells)

technique(s)

cell culture | mammalian: suitable

storage temp.

-140 to -196°C

Related Categories

General description

Human iPSC-Derived Microglia. Cells derived from male (BX-0900-30-1M) and female (BX-0900-32-1M) lines available. GFP-expressing neurons also available (BX-0901-30-1M). A major immune cell within the central nervous system (CNS), microglia are responsible for eliminating dead neurons, microbes, protein aggregates, and other particulates like degenerating synapses and myelin debris that are in the CNS. They also help to maintain neuronal networks, aid in injury repair, and mediate neuroinflammation. Microglia are implicated in neurodegeneration and aging, and are used to study autism, epilepsy, Alzheimer’s disease, and Huntington’s disease.

Application

Function: Human Microglia demonstrate phagocytosis and can be stimulated to secrete a variety of cytokines.

Features and Benefits

Marker Expression: Fully differentiated with confirmed expression of microglia surface markers including: CD45, CD11b, CX3CR1, P2RY12, and TMEM119. Immunocytochemistry shortly after plating microglia (shown here with a DAPI stain) reveals prominent expression of TREM2 (green) and IBA1 (red).

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