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Merck
CN

BX-0600-30

Human Cortical Astrocytes

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Human iPSC line, Fully differentiated, Healthy Male Control (no known neurological disorders), Cryopreserved

Synonym(s):

Cerebral Astrocytes

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biological source

human (iPSC line)

form

frozen liquid

packaging

vial of 1 (contains ≥1 million cells)

technique(s)

cell culture | mammalian: suitable

storage temp.

-140 to -196°C

Related Categories

General description

Human iPSC-Derived Cortical Astrocytes. Required supplements for the final cell differentiation and maturation (sold separately): BX-2600-100uL, BX-2020-100uL. Specialized glia that are the majority of the central nervous system (CNS), astrocytes do not conduct electrical signals but promote the health of the CNS through regulating the blood-brain barrier (BBB), excess neurotransmitter clearance, and maintaining ion balance, and more. Related diseases: Autism, Epilepsy, AD, HD

Application

Function: Cortical Astrocytes uptake glutamate. Improved neurite outgrowth in the presence of astrocytes. Energy and structural support cell for cortical neurons and immune response.

Features and Benefits

Marker Expression and Morphology: Fully differentiated Cortical Astrocytes express key astrocyte markers GFAP (green) and S100β (red) at >90% and exhibit mature process-bearing morphologies (shown here with a DAPI stain).

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Single-cell analysis reveals inflammatory interactions driving macular degeneration
Manik Kuchroo, Marcello DiStasio , Eric Song, Eda Calapkulu, et.al.
Nature Communications, 1 (2023)

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