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B9684

Sigma-Aldrich

Anti-Brn3a antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Brn3A Antibody, Brn3A Antibody - Anti-Brn3a antibody produced in rabbit, Anti-FLJ13449, Anti-OCT-T1, Anti-POU4F1, Anti-RDC1
MDL number:
MFCD02262629
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 42.9 kDa

species reactivity

human

species reactivity (predicted by homology)

mouse

technique(s)

immunocytochemistry: 1:200-1:1000
immunohistochemistry (frozen sections): 1:200-1:1000
western blot: 1:200-1:1000

UniProt accession no.

Q01851

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... POU4F1(5457)
mouse ... Pou4f1(18996)
rat ... Pou4f1(114503)

General description

Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Immunogen

POU4F1 / BRN3A antibody was raised against synthetic peptide (aa 141-157, AGGGGAHDGPGGGGGPG) corresponding to human Brn3a (BSA conjugated). Percent identity by BLAST analysis: Human (100%); Mouse (94%); Drosophila (82%).

Epitope
aa141-157

Physical form

Supplied in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Product No.
Description
Pricing

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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The retina communicates with the brain using ≥30 parallel channels, each carried by axons of distinct types of retinal ganglion cells. In every mammalian retina one finds so-called "alpha" ganglion cells (αRGCs), identified by their large cell bodies, stout axons
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In mammals, hair cells and auditory neurons lack the capacity to regenerate, and damage to either cell type can result in hearing loss. Replacement cells for regeneration could potentially be made by directed differentiation of human embryonic stem (hES) cells.
Hans Jürgen Wester et al.
Theranostics, 5(6), 618-630 (2015-04-01)
Chemokine ligand-receptor interactions play a pivotal role in cell attraction and cellular trafficking, both in normal tissue homeostasis and in disease. In cancer, chemokine receptor-4 (CXCR4) expression is an adverse prognostic factor. Early clinical studies suggest that targeting CXCR4 with

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