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B9429

Sigma-Aldrich

Anti-Bcl-xL antibody, Mouse monoclonal

~2 mg/mL, clone 2H12, purified from hybridoma cell culture

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

2H12, monoclonal

form

buffered aqueous solution

mol wt

antigen 27 kDa

species reactivity

rat, mouse, human

concentration

~2 mg/mL

technique(s)

microarray: suitable
western blot: 25-100 μg/mL using human epidermoid carcinoma A431 cell extract

isotype

IgG2a

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BCL2L1(598)
mouse ... Bcl2l1(12048)
rat ... Bcl2l1(24888)

Specificity

The antibody reacts with Bcl-xL protein, but not with Bcl-xS.

Immunogen

synthetic peptide corresponding to amino acids 3-14 shared by murine and human Bcl-xL, conjugated to KLH.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Physical form

Solution in phosphate buffered saline, pH 7.4 containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Peter F Vitiello et al.
Free radical biology & medicine, 44(3), 367-374 (2008-01-25)
The tumor suppressor protein p53 activates growth arrest and proapoptotic genes in response to DNA damage. It is known that negative feedback by p21(Cip1/Waf1/Sdi1) represses p53-dependent transactivation of PUMA. The current study investigates PUMA feedback on p53 during oxidative stress
A Notte et al.
Cell death & disease, 4, e638-e638 (2013-05-18)
Cancer cell resistance against chemotherapy is still a heavy burden to improve anticancer treatments. Autophagy activation and the development of hypoxic regions within the tumors are known to promote cancer cell resistance. Therefore, we sought to evaluate the role of
Kenichiro Doi et al.
The Journal of biological chemistry, 287(13), 10224-10235 (2012-02-09)
The anti-apoptotic Bcl-2 family of proteins, including Bcl-2, Bcl-X(L) and Mcl-1, are well-validated drug targets for cancer treatment. Several small molecules have been designed to interfere with Bcl-2 and its fellow pro-survival family members. While ABT-737 and its orally active
Vikash Kumar et al.
Oncotarget, 8(32), 53124-53136 (2017-09-09)
Ovarian cancer represents one of the most common malignancies among women with very high mortality rate worldwide. A-kinase anchor protein 4 (AKAP4), a unique cancer testis (CT) antigen has been shown to be associated with various malignant properties of cancer
Y T Hsu et al.
The Journal of biological chemistry, 272(21), 13829-13834 (1997-05-23)
Members of the Bcl-2 family (including Bcl-2, Bcl-XL, and Bax) play key roles in the regulation of apoptosis. These proteins are believed to be membrane-associated and have been proposed to regulate apoptosis through both homodimerization and heterodimerization. We have found

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