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Merck
CN

B9180

BW A868C

≥98% (HPLC)

Synonym(s):

3-[(2-Cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)- 4-imidazolidineheptanoic acid

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About This Item

Empirical Formula (Hill Notation):
C25H37N3O5
CAS Number:
118675-50-6
Molecular Weight:
459.58
NACRES:
NA.77
PubChem Substance ID:
329773313
UNSPSC Code:
12352200
MDL number:
MFCD00877696

Key Documents

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InChI

1S/C25H37N3O5/c29-22(20-13-7-4-8-14-20)17-26-28-21(15-9-1-2-10-16-23(30)31)24(32)27(25(28)33)18-19-11-5-3-6-12-19/h3,5-6,11-12,20-22,26,29H,1-2,4,7-10,13-18H2,(H,30,31)

SMILES string

OC(CNN1C(CCCCCCC(O)=O)C(=O)N(Cc2ccccc2)C1=O)C3CCCCC3

InChI key

YZJVWSKJHGEIBL-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

film

color

colorless

solubility

DMSO: 5 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

BW A868C is a potent, selective DP prostanoid receptor antagonist.

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
114M4733V
059K4718
056K47051
056K4705
104K47021

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G Monneret et al.
Blood, 98(6), 1942-1948 (2001-09-06)
Prostaglandin D2 (PGD2) is released following exposure of asthmatics to allergen and acts via the adenylyl cyclase-coupled receptor for PGD2 (DP receptor). In this study, it is reported that human eosinophils possess this receptor, which would be expected to inhibit
Hui Zhao et al.
Prostaglandins & other lipid mediators, 88(3-4), 68-72 (2008-11-15)
We found that prostaglandin (PG) D(2), the most abundant PG produced in the central nervous system (CNS), exhibited anxiolytic-like activity at a dose of 10-100pmol/mouse after intracerebroventricular (i.c.v.) administration in the elevated plus-maze test in mice. A DP(1) receptor-selective agonist
Md Ashequr Rahman et al.
European journal of pharmacology, 567(3), 245-251 (2007-06-05)
The present study was undertaken to investigate the involvement of chemical mediators in nasal allergic responses using histidine decarboxylase knockout (HDC-KO) mice. An allergic rhinitis model was developed in HDC-KO and wild-type mice by the intraperitoneal injection of ovalbumin, aluminum
N A Sharif et al.
British journal of pharmacology, 131(6), 1025-1038 (2000-11-18)
1. A potent and highly selective DP prostanoid receptor antagonist radioligand, [(3)H]-cyclohexyl-N-BWA868C (3-benzyl-5-(6-carboxyhexyl)-1-(2-cyclohexyl-2-hydroxyethyl-amino) hydantoin, ([(3)H]-BWA868C)), has been generated for receptor binding and autoradiographic studies. 2. Specific [(3)H]-BWA868C binding to human platelet membranes achieved equilibrium within 60 min at 23 degrees
T Minami et al.
The Journal of pharmacology and experimental therapeutics, 278(3), 1146-1152 (1996-09-01)
We previously reported that intrathecal administration of prostaglandin (PG) D2 and PGE2 to conscious mice induced hyperalgesia (assessed by a hot-plate test) and that intrathecal administration of PGE2 and PGF2 alpha induced allodynia, a state of discomfort and pain evoked
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