B8061
N-Butyl-N-(4-hydroxybutyl)nitrosamine
ISOPAC®, ≥90% (GC)
Synonym(s):
BBN, N-Butyl-N-butan-4-ol-nitrosamine, N-Butyl-N-nitroso-4-aminobutanol, OH-BBN
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About This Item
Empirical Formula (Hill Notation):
C8H18N2O2
CAS Number:
Molecular Weight:
174.24
MDL number:
UNSPSC Code:
12352116
NACRES:
NA.25
SMILES string
N(N=O)(CCCCO)CCCC
InChI
1S/C8H18N2O2/c1-2-3-6-10(9-12)7-4-5-8-11/h11H,2-8H2,1H3
InChI key
DIKPQFXYECAYPC-UHFFFAOYSA-N
assay
≥90% (GC)
form
liquid
storage temp.
2-8°C
Quality Level
Application
N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN), a carcinogen, is used to induce histiologically relevant aggressive urinary bladder cancer in animal models.
Biochem/physiol Actions
Carcinogen used to induce urinary bladder cancer in animal models. The result of exposure is histologically comparable to human urinary bladder tumorigenesis. Used in chemopreventative studies.
Packaging
Packaged in a 100 mL serum bottle with butyl rubber stopper and aluminum tear seal.
Preparation Note
Dissolving the contents in 100 mL of solvent yields a 1% solution.
Legal Information
Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Injecting any compatible solvent permits preparation of any desired strength solution without exposure.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
296.6 °F
flash_point_c
147 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Yuji Sagara et al.
Cancer epidemiology, 34(3), 350-354 (2010-04-07)
Green tea polyphenol (GTP) suppresses malignancy in bladder cancer cell lines. However, the detail of its anti-carcinogenic effect in vivo is not fully understood. This study investigated the effect of GTP on bladder tumor size and angiogenesis in mice given
Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model.
João C Fernandes et al.
Marine drugs, 10(12), 2661-2675 (2013-01-25)
Urinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange
Xiao-Li Xie et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(11), 3934-3940 (2012-08-15)
In the present study, effects of L-leucine and L-isoleucine on rat bladder carcinogenesis were investigated using AIN-93G and MF basal diet. In Experiment 1, N-butyl-N-(4-hydroxybutyl)-nitrosamine was used as an initiator of bladder carcinogenesis. In the AIN-93G diet groups, a significantly
Jun Miyazaki et al.
Anticancer research, 31(6), 2065-2071 (2011-07-09)
The present gold standard for bladder cancer is Mycobacterium bovis bacillus Calmette-Guérin (BCG) immunotherapy, but serious side-effects are common. We previously reported that C3H/HeN mice vaccinated with a mixture of MBT-2 cells and artificial BCG, octaarginine-modified liposomes incorporating the cell
Koji Nishizawa et al.
International journal of cancer, 127(5), 1180-1187 (2009-12-30)
We previously reported that the expression of CXC chemokine receptor-4 (CXCR4) was upregulated in invasive bladder cancers and that the small peptide T140 was a highly sensitive antagonist for CXCR4. In this study, we identified that CXCR4 expression was induced
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