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B7283

Benserazide hydrochloride

Name: Benserazide hydrochloride
Brand: SIGMA

≥98% (HPLC), solid, L-aromatic amino acid decarboxylase inhibitor

Synonym(s):

DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₅N₃O₅ · HCl

CAS Number:

14919-77-8

Molecular Weight:

293.70

EC Number:

238-991-9

MDL number:

MFCD00078571

UNSPSC Code:

12352125

PubChem Substance ID:

24277886

NACRES:

NA.77

product name

Benserazide hydrochloride, ≥98% (HPLC), solid

biological source

synthetic

Quality Level

100

Assay

≥98% (HPLC)

form

solid

solubility

H₂O: 10 mg/mL

originator

Roche

storage temp.

room temp

SMILES string

Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O

InChI

1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H

InChI key

ULFCBIUXQQYDEI-UHFFFAOYSA-N

Gene Information

human ... DDC(1644)

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General description

Benserazide is a peripheral decarboxylase inhibitor.

Application

Benserazide has been used:

to inhibit dopa-decarboxylase
to induce dyskinesia
to test on purified bacterial TDCs to assess the extent to which it could affect bacterial decarboxylases
as a peripheral dopa decarboxylase inhibitor to treat mice

Biochem/physiol Actions

Benserazide can block HK2 enzymatic activity in vitro. It is used along with levodopa to treat Parkinson′s disease.

Inhibitor of L-aromatic amino acid decarboxylase.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Restoration of the dopamine transporter through cell therapy improves dyskinesia in a rat model of Parkinson?s Disease

Tomas D, et al.

PLoS ONE, 11(4), e0153424-e0153424 (2016)

24 - Extrapyramidal movement disorders and spasticity

Waller DG, et al.

Medical Microbiology, 325-336 (2018)

Developmental and evolutionary basis for drought tolerance of the Anopheles gambiae embryo

Goltsev Y, et al.

Developmental Biology, 330(2), 462-470 (2009)

Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson?s disease

van KSP, et al.

Nature Communications, 10(1), 310-310 (2019)

Intestinal infection triggers Parkinson's disease-like symptoms in Pink1-/- mice.

Diana Matheoud et al.

Nature, 571(7766), 565-569 (2019-07-19)

Parkinson's disease is a neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons in the substantia nigra compacta. Although the mechanisms that trigger the loss of dopaminergic neurons are unclear, mitochondrial dysfunction and inflammation are thought to

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