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B7059

Sigma-Aldrich

Monoclonal Anti-Breast Cancer Resistance Protein antibody produced in mouse

~250 μg/mL, clone BXP-21, tissue culture supernatant, aqueous solution

Synonym(s):

Anti-ABCG2, Anti-BCRP

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About This Item

MDL number:
MFCD03791618
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

BXP-21, monoclonal

form

aqueous solution

mol wt

antigen ~70 kDa

species reactivity

human

concentration

~250 μg/mL

technique(s)

flow cytometry: suitable
immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable using pretreated human tissue
immunohistochemistry (frozen sections): 1:20 using acetone-fixed frozen sections
western blot: suitable

isotype

IgG2a

UniProt accession no.

Q9UNQ0

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ABCG2(9429)

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Specificity

Reacts with an internal epitope of BCRP. Does not cross-react with the human MDR1, MRP1, MRP2 gene products.

Immunogen

fusion protein containing human BCRP (amino acids 271-396) and maltose-binding protein.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Physical form

Supplied in serum-free medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Cathrine Elisabeth Olsen et al.
Biochemical pharmacology, 144, 63-77 (2017-08-09)
Here we report on the induction of resistance to photodynamic therapy (PDT) in the ABCG2-high human breast cancer cell line MA11 after repetitive PDT, using either Pheophorbide A (PhA) or di-sulphonated meso-tetraphenylchlorin (TPCS2a) as photosensitizer. Resistance to PhA-PDT was associated
Hong Qi et al.
Experimental eye research, 86(1), 34-40 (2007-11-06)
Nerve growth factor (NGF), a member of the neurotrophin family, has been identified as an essential growth factor supporting stem cell self-renewal outside the nervous system and was previously shown to stimulate corneal epithelial proliferation both in vivo and in

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