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B6312

Sigma-Aldrich

14-3-3 Beta histidine-tagged human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

14-3-3 β, 14-3-3 protein Beta, GW128, HS1, KCIP-1 protein 1054, YWHAB

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

recombinant

expressed in E. coli

Quality Level

Assay

≥90% (SDS-PAGE)

form

buffered aqueous glycerol solution

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... YWHAB(7529)

Biochem/physiol Actions

14-3-3 proteins are a multifunctional protein family comprising seven mammalian isoforms that interact with over two hundred different intracellular molecules including kinases, phosphatases, transcription factors, scaffold proteins, and DNA. 14-3-3 proteins are involved in a multitude of biological functions and play a regulatory role in processes such as apoptotic cell death, mitogenic signal transduction, and cell cycle control. 14-3-3 β participates in various processes, among which is the positive regulation of cell cycle progression and tumorigenesis. Over-expression of 14-3-3 β in NIH-3T3 cells confers tumorigenicity in nude mice via activation of the mitogen-activated protein kinase (MAPK) cascade.

Physical form

Supplied as a 0.2 μm filtered solution in 50 mM Tris, pH 7.6, 1 mM EDTA, 1 mM DTT and 20% glycerol (w/v).

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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