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Merck
CN

B5683

Betaxolol hydrochloride

>98% (HPLC), calcium channel blocker, solid

Synonym(s):

SL 75212

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About This Item

Empirical Formula (Hill Notation):
C18H29NO3 · HCl
CAS Number:
63659-19-8
Molecular Weight:
343.89
NACRES:
NA.77
PubChem Substance ID:
24278274
UNSPSC Code:
12352200
EC Number:
264-384-3
MDL number:
MFCD00242959

Key Documents

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Product Name

Betaxolol hydrochloride, >98% (HPLC)

InChI

1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H

InChI key

CHDPSNLJFOQTRK-UHFFFAOYSA-N

SMILES string

Cl[H].CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1

assay

>98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: soluble 36 mg/mL

originator

Alcon

Quality Level

100

Gene Information

human ... ADRB1(153)

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Application

Betaxolol hydrochloride has been used as a β1 blocking agent:
  • for the preparation of crystals of (R,S)-betaxolol (BE-IV).
  • to treat mammalian cells prior cell stimulation experiments.
  • to study the solid structure of metoprolol.

Biochem/physiol Actions

Betaxolol hydrochloride has the ability to block calcium channels. Betaxolol is a selective β1 adrenoreceptor antagonist. It has neuroprotective effects on retinal neurons.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Alcon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000198002
0000184405
0000198002
0000184405
0000113308

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Emmanuel Boucrot et al.
Nature, 517(7535), 460-465 (2014-12-18)
Endocytosis is required for internalization of micronutrients and turnover of membrane components. Endophilin has been assigned as a component of clathrin-mediated endocytosis. Here we show in mammalian cells that endophilin marks and controls a fast-acting tubulovesicular endocytic pathway that is
The beta-adrenoceptor antagonists metipranolol and timolol are retinal neuroprotectants: comparison with betaxolol
Wood J P M, et al.
Experimental Eye Research, 76(4) (2003)
J P M Wood et al.
Experimental eye research, 76(4), 505-516 (2003-03-14)
beta-adrenoceptor antagonists are used clinically to reduce elevated intraocular pressure in glaucoma which is characterised by a loss of retinal ganglion cells. Previous studies have shown that the beta(1)-selective adrenoceptor antagonist, betaxolol, is additionally able to protect retinal neurones in
I A Latfullin et al.
Klinicheskaia meditsina, 88(2), 68-71 (2010-11-26)
The use of beta-blockers is an important component of therapy of cardiovascular pathology (e.g. coronary heart disease, arterial hypertension) in menopausal women. Comparative data on the efficiency of lokren and carvedilol for the correction of grade 2 AH are presented.
The solid-state structure of the beta-blocker metoprolol: a combined experimental and in silico investigation
Rossi P, et al.
Acta Crystallographica Section C, Structural Chemistry, 75(2) (2019)
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