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B5683

Sigma-Aldrich

Betaxolol hydrochloride

>98% (HPLC)

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Synonym(s):
SL 75212
Empirical Formula (Hill Notation):
C18H29NO3 · HCl
CAS Number:
63659-19-8
Molecular Weight:
343.89
EC Number:
264-384-3
MDL number:
MFCD00242959
UNSPSC Code:
12352200
PubChem Substance ID:
24278274
NACRES:
NA.77

Quality Level

100

Assay

>98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: soluble 36 mg/mL

originator

Alcon

SMILES string

Cl[H].CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1

InChI

1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H

InChI key

CHDPSNLJFOQTRK-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153)

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Application

Betaxolol hydrochloride has been used as a β1 blocking agent:
  • for the preparation of crystals of (R,S)-betaxolol (BE-IV).
  • to treat mammalian cells prior cell stimulation experiments.
  • to study the solid structure of metoprolol.

Biochem/physiol Actions

Betaxolol hydrochloride has the ability to block calcium channels. Betaxolol is a selective β1 adrenoreceptor antagonist. It has neuroprotective effects on retinal neurons.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Alcon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Allergic contact dermatitis due to the beta-blocker betaxolol in eyedrops, with cross-sensitivity to timolol.
Massimiliano Nino et al.
Contact dermatitis, 62(5), 319-320 (2010-06-12)
Anders Heijl et al.
American journal of ophthalmology, 152(5), 842-848 (2011-08-17)
To analyze reduction of intraocular pressure (IOP) by argon laser trabeculoplasty (ALT) in the Early Manifest Glaucoma Trial and factors influencing the effect of such treatment. Cohort study based on 127 patients from the treatment group of the Early Manifest
The solid-state structure of the beta-blocker metoprolol: a combined experimental and in silico investigation
Rossi P, et al.
Acta Crystallographica Section C, Structural Chemistry, 75(2) (2019)
I A Latfullin et al.
Klinicheskaia meditsina, 88(2), 68-71 (2010-11-26)
The use of beta-blockers is an important component of therapy of cardiovascular pathology (e.g. coronary heart disease, arterial hypertension) in menopausal women. Comparative data on the efficiency of lokren and carvedilol for the correction of grade 2 AH are presented.
Yi Huang et al.
International journal of nanomedicine, 12, 1731-1745 (2017-03-11)
As a novel ion-exchange carrier with high surface area and excellent exchangeability, montmorillonite (Mt) was intercalated with betaxolol hydrochloride (BH) to form a nanocomposite and then encapsulated by liposomes (Mt-BH-LPs) for an ophthalmic drug-delivery system. The Mt-BH and Mt-BH-LPs were
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