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Merck
CN

B3313

Bicyclol

≥98% (HPLC)

Synonym(s):

4, 4′-dimethoxy-2, 3, 2′, 3′-bis(methylenedioxy)-6-hydroxymethyl-6′-methoxy-carbonyl biphenyl

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About This Item

Empirical Formula (Hill Notation):
C19H18O9
CAS Number:
118159-48-1
Molecular Weight:
390.34
NACRES:
NA.77
PubChem Substance ID:
329773215
UNSPSC Code:
12352202
MDL number:
MFCD00889471

Key Documents

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Product Name

Bicyclol, ≥98% (HPLC)

Quality Level

100

InChI

1S/C19H18O9/c1-22-11-4-9(6-20)13(17-15(11)25-7-27-17)14-10(19(21)24-3)5-12(23-2)16-18(14)28-8-26-16/h4-5,20H,6-8H2,1-3H3

SMILES string

COC(=O)c1cc(OC)c2OCOc2c1-c3c(CO)cc(OC)c4OCOc34

InChI key

KXMTXZACPVCDMH-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C.
Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C. The drug appears to protect against liver injury in animals. Recently it was reported that bicyclol induce the expression of hepatic HSP27 and HSP70, and thus consequently inhibits the transcription factor NF-?B-mediated apoptosis and necrosis in liver tissue. It appears that bicyclol induces hepatic HSP27 and HSP70 expression through activating transcription of HSPs genes.

General description

Bicyclol has anti-inflammatory properties and enhances the prognosis of kidney transplantation. It is involved in the removal of reactive oxygen species and modulates cytokine secretion.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
089K4602V
089K4602

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Protective effect of bicyclol on acute alcohol-induced liver injury in mice
Zhao J, et al.
European Journal of Pharmacology, 586(1-3), 322-331 (2008)
Qinge Ma et al.
Journal of ethnopharmacology, 195, 166-172 (2016-11-15)
Houttuynia cordata is an important traditional Chinese medicine used in heat-clearing and detoxifying, swelling and discharging pus, promoting diuresis and relieving stranguria which recorded in Pharmacopoeia of the people's Republic of China (2015 Edition). H. cordata has been recorded in
Effect of Bicyclol tablets on drug induced liver injuries after kidney transplantation
Shang W, et al.
Open Medicine : A Peer-Reviewed, Independent, Open-Access Journal, 12(1), 62-69 (2017)
Lijun Zhang et al.
International journal of biological macromolecules, 99, 63-70 (2017-02-09)
To study the characterization and hepatoprotective activity of polysaccharide from maca (Lepidium meyenii), the main polysaccharide from maca (MP-1) was obtained by DEAE-52 cellulose column. The average molecular weight of MP-1 was 1067.3kDa and the polysaccharide purity was 91.63%. In
Jing Wu et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 91, 1184-1192 (2017-05-26)
Renal cell carcinoma (RCC) is the most common subtype of kidney cancer. Currently, there is a lack of efficient treatment for RCC. Bicyclol, an anti-hepatitis drug, has been demonstrated to possess anti-tumor properties. However, the effect of bicyclol in RCC
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