All Photos(1)
Synonym(s):
α-methyl-5-(2-thienylmethoxy)-1H-Indole-3-ethanamine monohydrochloride
Empirical Formula (Hill Notation):
C16H18N2OS · HCl
CAS Number:
Molecular Weight:
322.85
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 1 mg/mL, clear
SMILES string
Cl.CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12
InChI
1S/C16H18N2OS.ClH/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14;/h2-6,8-9,11,18H,7,10,17H2,1H3;1H
InChI key
PYJBJMIBANAOFJ-UHFFFAOYSA-N
Gene Information
human ... HTR2B(3357)
Biochem/physiol Actions
5-HT2B serotonin receptor agonist.
Caution
Hygroscopic; photosensitive
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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G A Kennett et al.
Neuropharmacology, 36(2), 233-239 (1997-02-01)
The 5-HT2B receptor agonist, BW 723C86 (10 and 20 mg/kg s.c.), increased the time spent in feeding behaviour of freely-fed rats in observation cages over 15 min. BW 723C86 (20 and 50 mg/kg s.c. 30 min pre-test) also modestly increased
G A Kennett et al.
British journal of pharmacology, 117(7), 1443-1448 (1996-04-01)
1. BW 723C86 (3 and 10 mg kg-1, s.c. 30 min pretest), a 5-HT2B receptor agonist, increased total interaction, but not locomotion in a rat social interaction test, a profile consistent with anxiolysis. 2. The effect of BW 723C86 in
Marcus Niebert et al.
PloS one, 6(7), e21395-e21395 (2011-07-27)
Neurons of the respiratory network in the lower brainstem express a variety of serotonin receptors (5-HTRs) that act primarily through adenylyl cyclase. However, there is one receptor family including 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptors that are directed towards protein kinase
Yasmine Chabbi-Achengli et al.
The American journal of pathology, 186(4), 927-937 (2016-03-13)
Rheumatoid arthritis is a chronic disease that results in a disabling and painful condition as it progresses to destruction of the articular cartilage and ankylosis of the joints. Although the cause of the disease is still unknown, evidence argues that
Raphael R Perim et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 314(5), R709-R715 (2018-02-01)
Intermittent spinal serotonin receptor activation elicits phrenic motor facilitation (pMF), a form of spinal respiratory motor plasticity. Episodic activation of either serotonin type 2 (5-HT2) or type 7 (5-HT7) receptors elicits pMF, although they do so via distinct cellular mechanisms
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