Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

B1651

Sigma-Aldrich

Bradykinin Fragment 1-7

≥97% (HPLC)

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
1-7-Bradykinin
Empirical Formula (Hill Notation):
C35H52N10O9
CAS Number:
23815-87-4
Molecular Weight:
756.85
MDL number:
MFCD00076262
UNSPSC Code:
12352200
PubChem Substance ID:
24891606
NACRES:
NA.26

Quality Level

200

Assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P01161

storage temp.

−20°C

SMILES string

NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)N4CCCC4C(O)=O

InChI

1S/C35H52N10O9/c36-22(10-4-14-39-35(37)38)31(50)44-16-6-12-26(44)33(52)43-15-5-11-25(43)30(49)40-19-28(47)41-23(18-21-8-2-1-3-9-21)29(48)42-24(20-46)32(51)45-17-7-13-27(45)34(53)54/h1-3,8-9,22-27,46H,4-7,10-20,36H2,(H,40,49)(H,41,47)(H,42,48)(H,53,54)(H4,37,38,39)

InChI key

CRROPKNGCGVIOG-UHFFFAOYSA-N

Gene Information

rat ... Nppa(24602)

Related Categories

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro

General description

Bradykinin fragment 1-7 (BK-(1-7)), an endogenous peptide, is present in plasma.

Application

Bradykinin Fragment 1-7 has been used as an external calibrant/standard in the matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis of protein spots.
Bradykinin Fragment 1-7 is used in research on the specificity and kinetics of kininase(s).

Biochem/physiol Actions

Bradykinin (BK) is a pro-inflammatory mediator and a neuromediator. It modulates several vascular and renal functions. Bradykinin (BK) plays a key role in inducing vascular permeability and mitogenesis. It helps to activate the liberation of nitric oxide in inflammatory and cancer tissues.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

L Germain et al.
Journal of neuroimmunology, 13(2), 135-142 (1986-12-01)
The pathology of acute experimental allergic encephalomyelitis is characterized by perivascular cellular infiltrates in the central nervous system. Our hypothesis is that this immuno-pharmacological process can activate the circulating and tissular kallikrein-kinin systems. We studied 21 New Zealand rabbits inoculated
M Simmaco et al.
Biochimica et biophysica acta, 1033(3), 318-323 (1990-03-26)
The peptide fraction extracted by methanol from the skin of Rana esculenta, a species widely distributed in Western Europe, was investigated. The pharmacological activity found in the extract is attributable to the presence of authentic bradykinin, together with a shorter
L Germain et al.
Journal of the neurological sciences, 83(2-3), 211-217 (1988-02-01)
Experimental allergic encephalomyelitis (EAE) is a delayed cell-mediated autoimmune reaction to myelin basic protein. The neuropathology of this acute inflammatory process is characterized by cellular infiltration of the perivascular nervous parenchyma which increases the blood-brain barrier permeability. There is good
Darren Greetham et al.
Proteomics, 4(7), 1989-1995 (2004-06-29)
Phage display techniques using random peptide interactions have supported the role of mammalian glutathione transferase (GST) as part of a signalling pathway for both oxidative stress and an apoptosis pathway. Little is known about the interaction of nonmammalian GST with
Laura M Jones et al.
Journal of proteome research, 9(6), 2871-2881 (2010-04-16)
The insulin/insulin-like growth factor-1 (IGF-1) signaling system is a public regulator of aging in the model animals Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus. For the first time, proteomic analyses of the environmentally resistant and 'nonaging' C. elegans dauer stage
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service