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Merck
CN

B1401

Bradykinin Fragment 1-5

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C27H40N8O6
CAS Number:
23815-89-6
Molecular Weight:
572.66
NACRES:
NA.32
PubChem Substance ID:
24891591
UNSPSC Code:
12352200
MDL number:
MFCD00076260
Form:
powder
Assay:
≥97% (HPLC)

Key Documents

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InChI

1S/C27H40N8O6/c28-18(9-4-12-31-27(29)30)24(38)35-14-6-11-21(35)25(39)34-13-5-10-20(34)23(37)32-16-22(36)33-19(26(40)41)15-17-7-2-1-3-8-17/h1-3,7-8,18-21H,4-6,9-16,28H2,(H,32,37)(H,33,36)(H,40,41)(H4,29,30,31)

SMILES string

NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(O)=O

InChI key

USSUMSBPLJWFSZ-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

Quality Level

200

Gene Information

human ... KNG1 (includes EG:3827)

storage temp.

−20°C

Biochem/physiol Actions

The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6295
BCCG5734
BCBV6317
BCBR9832V
BCBM5382V

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J A Griswold et al.
Shock (Augusta, Ga.), 10(2), 146-152 (1998-08-29)
The purpose of this study was to assess the capacity of perfused rat hind limbs, the majority of which is skeletal muscle, to inactivate bradykinin (BK), and to compare the BK degrading capacity of rat hind limbs with the BK
Alejandro R Prieto et al.
Cardiovascular research, 53(4), 984-992 (2002-03-30)
Thrombin activates platelets and contributes to the occlusion of arteries following thrombolytic therapy or angioplasty. Thrombostatin (RPPGF), the angiotensin converting enzyme degradation product of bradykinin, inhibits alpha-thrombin induced platelet activation. We hypothesized that thrombostatin prevents platelet aggregation and adhesion after
F A Fernandez-Lima et al.
The journal of physical chemistry. A, 113(29), 8221-8234 (2009-07-03)
A new approach is described for the elucidation of gas-phase peptide ion structures combining ion mobility spectrometry (IMS) data and molecular dynamics (MD)-cluster analysis (CA) prediction. The new approach is based on the determination of the gas-phase ion structure identity
M Cugno et al.
Clinical science (London, England : 1979), 101(6), 651-657 (2001-11-29)
Bradykinin, a nonapeptide with vasodilatory and permeabilizing activity, is generated through the cleavage of high-M(r) ('high-molecular-weight') kininogen by kallikrein, and its generation is facilitated by plasmin. In the ascitic fluid of patients with cirrhosis, there is massive cleavage of high-M(r)
Mitsuhiro Hirata et al.
British journal of pharmacology, 135(1), 29-36 (2002-01-12)
1. The involvement of bradykinin (BK) B(2) receptor in acute pancreatitis induced by pancreaticobiliary duct ligation was investigated in rats. 2. The activities of amylase and lipase in the serum, the water content of the pancreas, and vacuolization of the
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