B0814
BMP-7 active human
Animal-component free, recombinant, expressed in Nicotiana, >97% (SDS-PAGE)
Synonym(s):
BMP7 human, Bone Morphogenetic Protein 7 human
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About This Item
UNSPSC Code:
51111800
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biological source
human
recombinant
expressed in Nicotiana
Assay
>97% (SDS-PAGE)
form
lyophilized
potency
≤40 ng/mL ED50
mol wt
16.5 kDa (single chain)
storage condition
avoid repeated freeze/thaw cycles
impurities
Endotoxin, tested (LAL test, < 0.04 EU/ μg protein)
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... BMP7(655)
Amino Acid Sequence
HisHisHisHisHisHisSerThrGlySerLysGlnArgSerGlnAsnArgSerLysThrProLysAsnGlnGluAlaLeuArgMetAlaAsnValAlaGluAsnSerSerSerAspGlnArgGlnAlaCysLysLysHisGluLeuTyrValSerPheArgAspLeuGlyTrpGlnAspTrpIleIleAlaProGluGlyTyrAlaAlaTyrTyrCysGluGlyGluCysAlaPheProLeuAsnSerTyrMetAsnAlaThrAsnHisAlaIleValGlnThrLeuValHisPheIleAsnProGluThrValProLysProCysCysAlaProThrGlnLeuAsnAlaIleSerValLeuTyrPheAspAspSerSerValIleLeuLysLysTyrArgAsnMetValValArgAlaCysGlyCysHis
General description
The bone morphogenetic proteins are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.
The bone morphogenetic proteins are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP1), is a widely expressed TGFb superfamily member with important functions during embryogenesis, in the adult, and in disease (Chen et al., 2004, Kishigami and Mishina 2005). BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (Sampath et al., 1992, Kazama et al., 2008), inhibits the branching of prostate epithelium (Grishina et al., 2005), and antagonizes epithelialmesenchymal transition (Zeisberg et al., 2003, Yu et al., 2009). In pathological conditions, BMP7 inhibits tumor growth and metastasis (Buijs et al., 2007), ameliorates fibrotic damage in nephritis (Zeisberg et al., 2003), and promotes neuroregeneration following brain ischemia (Chou et al., 2006).
Physical form
Lyophilized from a Tris HCl 0.05 M buffer at pH 7.4
Reconstitution
Lyophilized protein should be reconstituted in water to a concentration of 50 ng /μl.
Analysis Note
The biological activity of BMP-7 is measured by its ability to induce alkaline phosphatase production by ATDC5 cells.
ED50: ≤ 40 ng/mL
ED50: ≤ 40 ng/mL
Other Notes
Extinction Coefficient: E0.1% = 1.321 (A 280 nm)
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Yan Wang et al.
Experimental and molecular pathology, 98(3), 393-402 (2015-03-17)
This study presented the effect of bone morphogenic protein-7 (BMP-7) inhibiting epithelial-mesenchymal transition (EMT) in silicosis model. In vivo, Wistar rats were exposed to silica by intratracheal instillation. Seven days later rats were treated with BMP-7. Rats were sacrificed at
Sedat Odabas et al.
Methods in molecular biology (Clifton, N.J.), 1109, 47-63 (2014-01-30)
Mesenchymal stem cells (MSCs) have drawn great interest in the field of regenerative medicine, for cell replacement, immunomodulatory, and gene therapies. It has been shown that these multipotent stromal cells can be isolated from tissues such as bone marrow, adipose
Endre Kristóf et al.
Scientific reports, 5, 12540-12540 (2015-07-28)
Laser-scanning cytometry is presented as a tool allowing population scale analysis of ex vivo human brown adipogenic differentiation. It combines texture analysis and detection of Ucp1 protein content in single brown adipocytes of mixed cell populations with gene expression pattern
Pilar González-Gómez et al.
Oncotarget, 6(13), 10950-10963 (2015-04-11)
Glioblastoma tumor initiating cells are believed to be the main drivers behind tumor recurrence, and therefore therapies that specifically manage this population are of great medical interest. In a previous work, we synthesized controlled release microspheres optimized for intracranial delivery
Qiming Jin et al.
PloS one, 9(5), e97035-e97035 (2014-05-08)
Host blood circulating stem cells are an important cell source that participates in the repair of damaged tissues. The clinical challenge is how to improve the recruitment of circulating stem cells into the local wound area and enhance tissue regeneration.
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