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Key Documents

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Safety Information

B0515

Sigma-Aldrich

Betamethasone 17-valerate

Synonym(s):

1,4-Pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-valerate, 9α-Fluoro-16β-methylprednisolone 17-valerate, Betnovate

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About This Item

Empirical Formula (Hill Notation):
C27H37FO6
CAS Number:
2152-44-5
Molecular Weight:
476.58
Beilstein:
4240001
MDL number:
MFCD00867446
UNSPSC Code:
12352200
PubChem Substance ID:
24891523
NACRES:
NA.77
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form

powder

originator

Schering Plough

storage temp.

2-8°C

SMILES string

CCCCC(=O)O[C@@]1([C@@H](C)CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)CO

InChI

1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19?,20?,21-,24-,25-,26-,27-/m0/s1

InChI key

SNHRLVCMMWUAJD-QDHNOTTGSA-N

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Show Differences

1 of 4

This Item
PHR1780B1152D1756
Betamethasone 17-valerate

B0515

Betamethasone 17-valerate

Betamethasone Valerate Pharmaceutical Secondary Standard; Certified Reference Material

PHR1780

Betamethasone Valerate

Betamethasone 17,21-dipropionate

B1152

Betamethasone 17,21-dipropionate

Dexamethasone ≥98% (HPLC), powder

D1756

Dexamethasone

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

originator

Schering Plough

originator

-

originator

Schering Plough

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

Biochem/physiol Actions

Betamethasone 17-valerate is a synthetic glucocorticoid. It exhibitstherapeutic effects against various allergic and inflammatory skin diseases.[1] Betamethasone 17-valerate also possesses anti-inflammatory properties.[2]

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360FD,H373

Hazard Classifications

Repr. 1B - STOT RE 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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    Certificates of Analysis (COA)

    Lot/Batch Number
    SLBS8916
    031M1176V
    077K1400
    102K1561
    106K1615

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    Effect of five anti-inflammatory steroids on collagen and glycoaminoglycan synthessis in vitro
    Saarni H, et al.
    British Journal of Dermatology, 103(2), 167-173 (1980)
    L B Jensen et al.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 79(1), 68-75 (2011-06-15)
    Treatment of skin diseases implies application of a drug to skin with an impaired epidermal barrier, which is likely to affect the penetration profile of the drug substance as well as the carrier into the skin. To elucidate this, the
    Taner Senyiğit et al.
    International journal of pharmaceutics, 403(1-2), 123-129 (2010-11-05)
    The aim of this study was to evaluate the suitability of sodium-deoxycholate (Na-DOC) gels containing betamethasone-17-valerate (BMV) for topical application. The gels were characterized for rheological and textural properties. The in vitro flux of BMV from Na-DOC gels across rat
    Atsuko Kamo et al.
    Journal of dermatological science, 62(2), 91-97 (2011-04-05)
    UV-based therapy has anti-pruritic effects in inflammatory skin diseases, such as atopic dermatitis and psoriasis. These anti-pruritic effects may be partly due to inhibition of intraepidermal nerve growth, but they have not been fully characterized. This study was performed to
    Rosita Saraceno et al.
    The Journal of dermatological treatment, 21(6), 363-366 (2010-06-12)
    Prurigo nodularis is a distressing condition characterized by the presence of multiple nodules associated with intense pruritus. To assess the clinical efficacy and safety of betamethasone valerate 0.1% tape and a moisturizing itch-relief cream in prurigo nodularis. Twelve patients were
    View All Related Papers

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