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B0385

Sigma-Aldrich

Beclomethasone

≥99%

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Synonym(s):
9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
Empirical Formula (Hill Notation):
C22H29ClO5
CAS Number:
4419-39-0
Molecular Weight:
408.92
EC Number:
224-585-9
MDL number:
MFCD00135614
UNSPSC Code:
12352200
PubChem Substance ID:
24278253
NACRES:
NA.77

Quality Level

100

Assay

≥99%

form

powder

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

[H][C@]12C[C@@H](C)[C@@](O)(C(=O)CO)[C@]1(C)C[C@@H](O)[C@@]3(Cl)[C@]2([H])CCC4=CC(=O)C=C[C@@]34C

InChI

1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12?,15?,16?,17?,19?,20?,21-,22?/m0/s1

InChI key

NBMKJKDGKREAPL-WOOYFSPWSA-N

Gene Information

human ... CYP1A2(1544)

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Application

Beclomethasone has been used in MS−MS (mass spectrometry) methods for the analysis of β-agonists, corticosteroids, chloramphenicol and penicillins. It has also been used to find the differential response of glucocorticoids in larval regeneration model.

Biochem/physiol Actions

Beclomethasone is an anti-inflammatory glucocorticoid.
It helps to decrease airway hyperresponsiveness. It also helps to regulate symptoms of asthma.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

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Lydia J Finney et al.
The Journal of allergy and clinical immunology, 147(2), 510-519 (2020-10-18)
The mechanisms underlying altered susceptibility and propensity to severe Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with chronic obstructive pulmonary disease (COPD) are poorly understood. Inhaled corticosteroids (ICSs) are widely used in COPD, but the extent
A comparative analysis of changes in pMDI drug dose delivery before and after detergent coating using five antistatic valved holding chambers.
Paul Hagedoorn et al.
The journal of allergy and clinical immunology. In practice, 8(3), 1124-1125 (2019-10-09)
A comparison of beclomethasone, salmeterol, and placebo in children with asthma
Simons, FER, et al.
The New England Journal of Medicine, 337(23), 1659-1665 (1997)
Hong Ping Zhang et al.
Allergy and asthma proceedings, 35(4), 278-287 (2014-07-06)
It has proven efficacy in reducing asthma exacerbations, but the effect size of montelukast (a leukotriene receptor antagonist) for varied severity of asthma exacerbations is not systematically assessed. This study was designed to systematically explore the evidence for montelukast, as
Antonia Chatzopoulou et al.
Molecular and cellular endocrinology, 447, 61-70 (2017-03-01)
In humans, two splice variants of the glucocorticoid receptor (GR) exist: the canonical α-isoform, and the β-isoform, which has been shown to have a dominant-negative effect on hGRα. Previously, we have established the occurrence of a GR β-isoform in zebrafish
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