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Merck
CN

B019

Phenoxybenzamine hydrochloride

≥97%, powder

Synonym(s):

N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H22ClNO · HCl
CAS Number:
63-92-3
Molecular Weight:
340.29
NACRES:
NA.77
PubChem Substance ID:
24277760
UNSPSC Code:
12352116
EC Number:
200-569-7
MDL number:
MFCD00055152

Key Documents

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InChI key

VBCPVIWPDJVHAN-UHFFFAOYSA-N

InChI

1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H

SMILES string

Cl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2

assay

≥97%

form

powder

color

white

solubility

H2O: slightly soluble, alcohol: soluble, propylene glycol: soluble

originator

Wellspring

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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Biochem/physiol Actions

Calmodulin antagonist; α-adrenoceptor antagonist.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

hcodes

H302,H351

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ2037
MKCN3537
MKCL8599
MKCK4939
MKCD4626

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Is dexmedetomidine the agent of choice in the resection of pheochromocytoma?
Harsha V Polavarapu et al.
The American surgeon, 78(3), E127-E128 (2012-04-25)
João Walter S Silveira et al.
Molecular pain, 6, 17-17 (2010-03-25)
Descending pronociceptive pathways may be implicated in states of persistent pain. Paw skin incision is a well-established postoperative pain model that causes behavioral nociceptive responses and enhanced excitability of spinal dorsal horn neurons. The number of spinal c-Fos positive neurons
Brian T Welch et al.
Radiology, 258(1), 301-307 (2010-10-26)
To assess safety, technical success, complications, and hemodynamic changes associated with the adrenal cryoablation procedure. This retrospective review was approved by the institutional review board, with waiver of informed consent, and was compliant with the Health Insurance Portability and Accountability
Yu Zhu et al.
Endocrine, 38(2), 254-259 (2010-11-04)
The objective of this article is to evaluate the efficacy of Doxazosin Mesylate Controlled Release Tablets for preoperative treatment of patients with pheochromocytoma. Between 2003 and 2008, 67 patients with confirmed diagnoses of pheochromocytoma were enrolled in this study. According
Y M Ning et al.
Molecular endocrinology (Baltimore, Md.), 10(1), 14-23 (1996-01-01)
The glucocorticoid receptor (GR) is a ligand-regulated transcription factor whose ability to bind hormone is thought to be dependent on association with the 90-kDa heat shock protein (hsp90). In the present study, we have generated a novel form of the
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